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- Oxygenated blood travels from the lungs through the pulmonary veins and into the left side of the heart, which pumps the blood to the rest of the body (see Function of the Heart). Oxygen-deficient, carbon dioxide-rich blood returns to the right side of the heart through two large veins, the superior vena cava and the inferior vena cava.
www.merckmanuals.com/home/lung-and-airway-disorders/biology-of-the-lungs-and-airways/exchanging-oxygen-and-carbon-dioxideExchanging Oxygen and Carbon Dioxide - Exchanging Oxygen and ...
The oxygen transport cascade describes the physiological ‘steps’ that bring atmospheric oxygen into the body where it is delivered and consumed by metabolically active tissue. As such, the oxygen cascade is fundamental to our understanding of exercise in health and disease.
Mar 10, 2021 · Important to exercise, the ODC is influenced by pH, temperature, and CO 2 — and 2-3 bisphosphoglyceric acid, with lower pH, higher temperature, and higher CO 2 causing a decrease in affinity or right shift and making it easier to unload oxygen at the tissues, especially active skeletal muscle.
- Paolo B. Dominelli, Chad C. Wiggins, Tuhin K. Roy, Timothy W. Secomb, Timothy B. Curry, Michael J. J...
- 2021
Oxygen-deficient, carbon dioxide-rich blood returns to the right side of the heart through two large veins, the superior vena cava and the inferior vena cava. Then the blood is pumped through the pulmonary artery to the lungs, where it picks up oxygen and releases carbon dioxide.
Apr 14, 2017 · The transportation route relies on red blood cells which contain oxygen-binding molecules called hemoglobin. Every second, your body churns about 2.5 million blood cells, so the oxygen sent to your lungs has a vast amount of transportation.
- Janissa Delzo
- Overview
- Interplay of respiration, circulation, and metabolism
The interplay of respiration, circulation, and metabolism is the key to the functioning of the respiratory system as a whole. Cells set the demand for oxygen uptake and carbon dioxide discharge, that is, for gas exchange in the lungs. The circulation of the blood links the sites of oxygen utilization and uptake. The proper functioning of the respiratory system depends on both the ability of the system to make functional adjustments to varying needs and the design features of the sequence of structures involved, which set the limit for respiration.
The main purpose of respiration is to provide oxygen to the cells at a rate adequate to satisfy their metabolic needs. This involves transport of oxygen from the lung to the tissues by means of the circulation of blood. In antiquity and the medieval period, the heart was regarded as a furnace where the “fire of life” kept the blood boiling. Modern cell biology has unveiled the truth behind the metaphor. Each cell maintains a set of furnaces, the mitochondria, where, through the oxidation of foodstuffs such as glucose, the energetic needs of the cells are supplied. The precise object of respiration therefore is the supply of oxygen to the mitochondria.
Cell metabolism depends on energy derived from high-energy phosphates such as adenosine triphosphate (ATP), whose third phosphate bond can release a quantum of energy to fuel many cell processes, such as the contraction of muscle fibre proteins or the synthesis of protein molecules. In the process, ATP is degraded to adenosine diphosphate (ADP), a molecule with only two phosphate bonds. To recharge the molecule by adding the third phosphate group requires energy derived from the breakdown of foodstuffs, or substrates. Two pathways are available: (1) anaerobic glycolysis, or fermentation, which operates in the absence of oxygen; and (2) aerobic metabolism, which requires oxygen and involves the mitochondria. The anaerobic pathway leads to acid waste products and is wasteful of resources: The breakdown of one molecule of glucose generates only two molecules of ATP. In contrast, aerobic metabolism has a higher yield (36 molecules of ATP per molecule of glucose) and results in “clean wastes”—water and carbon dioxide, which are easily eliminated from the body and are recycled by plants in the process of photosynthesis. For any sustained high-level cell activity, the aerobic metabolic pathway is therefore preferable. Since oxidative phosphorylation occurs only in mitochondria, and since each cell must produce its own ATP (it cannot be imported), the number of mitochondria in a cell reflects its capacity for aerobic metabolism, or its need for oxygen.
The supply of oxygen to the mitochondria at an adequate rate is a critical function of the respiratory system, because the cells maintain only a limited store of high-energy phosphates and of oxygen, whereas they usually have a reasonable supply of substrates in stock. If oxygen supply is interrupted for a few minutes, many cells, or even the organism, will die.
Oxygen is collected from environmental air, transferred to blood in the lungs, and transported by blood flow to the periphery of the cells where it is discharged to reach the mitochondria by diffusion. The transfer of oxygen to the mitochondria involves several structures and different modes of transports. It begins with ventilation of the lung, which is achieved by convection or mass flow of air through an ingeniously branched system of airways. In the most peripheral airways, ventilation of alveoli is completed by diffusion of oxygen through the air to the alveolar surface. The transfer of oxygen from alveolar air into the capillary blood occurs by diffusion across the tissue barrier; it is driven by the oxygen partial pressure difference between alveolar air and capillary blood and depends on the thickness (about 0.5 μm [1 μm = 0.000039 inch]) and the surface area (about 130 square metres [about 1,400 square feet] in humans) of the barrier. Convective transport by the blood depends on the blood flow rate (cardiac output) and on the oxygen capacity of the blood, which is determined by its content of hemoglobin in red blood cells. The last step is the diffusive discharge of oxygen from the capillaries into the tissue and cells, which is driven by the oxygen partial pressure difference and depends on the quantity of capillary blood in the tissue. In this process the blood plays a central role and affects all transport steps: oxygen uptake in the lung, transport by blood flow, and discharge to the cells. Blood also serves as carrier for both respiratory gases: oxygen, which is bound to hemoglobin in the red blood cells, and carbon dioxide, which is carried by both plasma and red blood cells and which also serves as a buffer for acid-base balance in blood and tissues.
Metabolism, or, more accurately, the metabolic rate of the cells, sets the demand for oxygen. At rest a human consumes about 250 ml (about 15 cubic inches) of oxygen each minute. With exercise this rate can be increased more than 10-fold in a normal healthy individual, but a highly trained athlete may achieve a more than 20-fold increase. As more and more muscle cells become engaged in doing work, the demand for ATP and oxygen increases linearly with work rate. This is accompanied by an increased cardiac output, essentially due to a higher heart rate, and by increased ventilation of the lungs; as a consequence, the oxygen partial pressure difference across the air–blood barrier increases and oxygen transfer by diffusion is augmented. These dynamic adjustments to the muscles’ needs occur up to a limit that is twice as high in the athlete as in the untrained individual. This range of possible oxidative metabolism from rest to maximal exercise is called the aerobic scope. The upper limit to oxygen consumption is not conferred by the ability of muscles to do work, but rather by the limited ability of the respiratory system to provide or utilize oxygen at a higher rate. Muscle can do more work, but beyond the aerobic scope they must revert to anaerobic metabolism, with the result that waste products, mainly lactic acid, accumulate and limit the duration of work.
The interplay of respiration, circulation, and metabolism is the key to the functioning of the respiratory system as a whole. Cells set the demand for oxygen uptake and carbon dioxide discharge, that is, for gas exchange in the lungs. The circulation of the blood links the sites of oxygen utilization and uptake. The proper functioning of the respiratory system depends on both the ability of the system to make functional adjustments to varying needs and the design features of the sequence of structures involved, which set the limit for respiration.
The main purpose of respiration is to provide oxygen to the cells at a rate adequate to satisfy their metabolic needs. This involves transport of oxygen from the lung to the tissues by means of the circulation of blood. In antiquity and the medieval period, the heart was regarded as a furnace where the “fire of life” kept the blood boiling. Modern cell biology has unveiled the truth behind the metaphor. Each cell maintains a set of furnaces, the mitochondria, where, through the oxidation of foodstuffs such as glucose, the energetic needs of the cells are supplied. The precise object of respiration therefore is the supply of oxygen to the mitochondria.
Cell metabolism depends on energy derived from high-energy phosphates such as adenosine triphosphate (ATP), whose third phosphate bond can release a quantum of energy to fuel many cell processes, such as the contraction of muscle fibre proteins or the synthesis of protein molecules. In the process, ATP is degraded to adenosine diphosphate (ADP), a molecule with only two phosphate bonds. To recharge the molecule by adding the third phosphate group requires energy derived from the breakdown of foodstuffs, or substrates. Two pathways are available: (1) anaerobic glycolysis, or fermentation, which operates in the absence of oxygen; and (2) aerobic metabolism, which requires oxygen and involves the mitochondria. The anaerobic pathway leads to acid waste products and is wasteful of resources: The breakdown of one molecule of glucose generates only two molecules of ATP. In contrast, aerobic metabolism has a higher yield (36 molecules of ATP per molecule of glucose) and results in “clean wastes”—water and carbon dioxide, which are easily eliminated from the body and are recycled by plants in the process of photosynthesis. For any sustained high-level cell activity, the aerobic metabolic pathway is therefore preferable. Since oxidative phosphorylation occurs only in mitochondria, and since each cell must produce its own ATP (it cannot be imported), the number of mitochondria in a cell reflects its capacity for aerobic metabolism, or its need for oxygen.
The supply of oxygen to the mitochondria at an adequate rate is a critical function of the respiratory system, because the cells maintain only a limited store of high-energy phosphates and of oxygen, whereas they usually have a reasonable supply of substrates in stock. If oxygen supply is interrupted for a few minutes, many cells, or even the organism, will die.
Oxygen is collected from environmental air, transferred to blood in the lungs, and transported by blood flow to the periphery of the cells where it is discharged to reach the mitochondria by diffusion. The transfer of oxygen to the mitochondria involves several structures and different modes of transports. It begins with ventilation of the lung, which is achieved by convection or mass flow of air through an ingeniously branched system of airways. In the most peripheral airways, ventilation of alveoli is completed by diffusion of oxygen through the air to the alveolar surface. The transfer of oxygen from alveolar air into the capillary blood occurs by diffusion across the tissue barrier; it is driven by the oxygen partial pressure difference between alveolar air and capillary blood and depends on the thickness (about 0.5 μm [1 μm = 0.000039 inch]) and the surface area (about 130 square metres [about 1,400 square feet] in humans) of the barrier. Convective transport by the blood depends on the blood flow rate (cardiac output) and on the oxygen capacity of the blood, which is determined by its content of hemoglobin in red blood cells. The last step is the diffusive discharge of oxygen from the capillaries into the tissue and cells, which is driven by the oxygen partial pressure difference and depends on the quantity of capillary blood in the tissue. In this process the blood plays a central role and affects all transport steps: oxygen uptake in the lung, transport by blood flow, and discharge to the cells. Blood also serves as carrier for both respiratory gases: oxygen, which is bound to hemoglobin in the red blood cells, and carbon dioxide, which is carried by both plasma and red blood cells and which also serves as a buffer for acid-base balance in blood and tissues.
Metabolism, or, more accurately, the metabolic rate of the cells, sets the demand for oxygen. At rest a human consumes about 250 ml (about 15 cubic inches) of oxygen each minute. With exercise this rate can be increased more than 10-fold in a normal healthy individual, but a highly trained athlete may achieve a more than 20-fold increase. As more and more muscle cells become engaged in doing work, the demand for ATP and oxygen increases linearly with work rate. This is accompanied by an increased cardiac output, essentially due to a higher heart rate, and by increased ventilation of the lungs; as a consequence, the oxygen partial pressure difference across the air–blood barrier increases and oxygen transfer by diffusion is augmented. These dynamic adjustments to the muscles’ needs occur up to a limit that is twice as high in the athlete as in the untrained individual. This range of possible oxidative metabolism from rest to maximal exercise is called the aerobic scope. The upper limit to oxygen consumption is not conferred by the ability of muscles to do work, but rather by the limited ability of the respiratory system to provide or utilize oxygen at a higher rate. Muscle can do more work, but beyond the aerobic scope they must revert to anaerobic metabolism, with the result that waste products, mainly lactic acid, accumulate and limit the duration of work.
Duling suggested that there were two possibilities that might explain this finding: (1) the oxygen supply might be regulated by a direct effect on vascular smooth muscle or (2) oxygen acts only through cellular metabolism and that the rate of oxygen delivery to cells, rather than the absolute P O 2, would be regulated.
Aug 6, 2018 · Body cells use oxygen to convert stored energy. This process, which is called cellular respiration, allows the cells to harness energy to perform vital functions such as the movement of materials into and out of cells.
