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Apr 3, 2024 · Over time, repeated activation of the stress response takes a toll on the body. Research suggests that chronic stress contributes to high blood pressure, promotes the formation of artery-clogging deposits, and causes brain changes that may contribute to anxiety, depression, and addiction.
- hhp_info@health.harvard.edu
May 7, 2024 · Stress response is a nuanced interplay among diverse brain centers, particularly the neural mechanisms responsible for triggering stress reactions, which include the locus coeruleus, limbic system, and hypothalamic efferent activation complex.
- Brianna Chu, Komal Marwaha, Terrence Sanvictores, Derek Ayers
- 2024/05/07
- 2019
Some studies have shown that stress has many effects on the human nervous system and can cause structural changes in different parts of the brain (Lupien et al., 2009 [65]). Chronic stress can lead to atrophy of the brain mass and decrease its weight (Sarahian et al., 2014 [100]).
The brain is the key organ of the response to stress because it determines what is threatening and, therefore, potentially stressful, as well as the physiological and behavioral responses which can be either adaptive or damaging.
- Bruce S. McEwen
- 2007
Oct 17, 2020 · Stress constitutes a state of threatened homeostasis triggered by intrinsic or extrinsic adverse forces (stressors) and is counteracted by an intricate repertoire of physiologic and behavioral responses aiming to maintain/reestablish the optimal body equilibrium (eustasis).
- Constantine Tsigos, Ioannis Kyrou, Eva Kassi, George P. Chrousos
- 2020/10/17
- 2016
Stress can cause an imbalance of neural circuitry subserving cognition, decision making, anxiety and mood that can increase or decrease expression of those behaviors and behavioral states. This imbalance, in turn, affects systemic physiology via neuroendocrine, autonomic, immune and metabolic mediators.
In this review article, we briefly describe the history of stress research and highlight stress basic concepts, explore the complex neuroanatomy, in fact networks, of the stress system and its keen axes and mediators, as well as the time domains of the stress response.
