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Heart development, also known as cardiogenesis, refers to the prenatal development of the heart. This begins with the formation of two endocardial tubes which merge to form the tubular heart, also called the primitive heart tube. The heart is the first functional organ in vertebrate embryos.
The human heart is the first functional organ to develop. It begins beating and pumping blood around day 21 or 22, a mere three weeks after fertilization. This emphasizes the critical nature of the heart in distributing blood through the vessels and the vital exchange of nutrients, oxygen, and wastes both to and from the developing baby.
- Lindsay M. Biga, Sierra Dawson, Amy Harwell, Robin Hopkins, Joel Kaufmann, Mike LeMaster, Philip Mat...
- 2019
Aug 17, 2023 · Heart conductive system (histological slide) Initially, the primordial atrium functions as the developing heart’s pacemaker; but the sinus venosus soon takes over this role. In the fifth week, the sinuatrial (SA) node develops in the right atrium near the opening of the SVC. After the sinus venosus is integrated into the heart, cells from its ...
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In human embryos the heart begins to beat at about 22-23 days, with blood flow beginning in the 4th week. The heart is therefore one of the earliest differentiating and functioning organs. The heart begins very early in mesoderm within the trilaminar embryonic disc. The heart forms initially in the embryonic disc as a simple paired tube inside the ...
UNSW Embryology
Hill, M.A. (2020). UNSW Embryology (20th ed.) Retrieved August 17, 2024, from https://embryology.med.unsw.edu.au Heart Tutorial | 2013 Lecture Slides
The Developing Human: Clinically Oriented Embryology
Moore, K.L., Persaud, T.V.N. & Torchia, M.G. (2015). The developing human: clinically oriented embryology(10th ed.). Philadelphia: Saunders. (links available to UNSW students) 1. Cardiovascular System
Larsen's Human Embryology
Schoenwolf, G.C., Bleyl, S.B., Brauer, P.R., Francis-West, P.H. & Philippa H. (2015). Larsen's human embryology(5th ed.). New York; Edinburgh: Churchill Livingstone. (links available to UNSW students) 1. Development of the Heart 2. Development of the Vasculature 1. Links: Embryology Textbooks 1. Human Embryology(2nd ed.) Larson Ch7 p151-188 Heart 2. The Developing Human: Clinically Oriented Embryology(6th ed.) Moore and Persaud Ch14: p304-349 3. Before we Are Born(5th ed.) Moore and Persaud C...
Cardiogenic region - in splanchnic mesenchyme of prechordal plate regionWeek 2 pair of thin-walled tubespericardium- covers the heart, formed by 3 layers consisting of a fibrous pericardium and a double layered serous pericardium (parietal layer and visceral epicardium layer).myocardium- muscular wall of the heart, thickest layer formed by spirally arranged cardiac muscle cells.endocardium- lines the heart, epithelial tissue lining the inner surface of heart chambers and valves.Historic Images
1. Fig. 528. Heart of a Rabbit Embryo seen from behind at 3.4 mm head length 2. Fig. 529. The heart of a 24 mm Embryo 3. Fig. 530. Fetal heart (6 months) in normal situation 4. Fig. 531. Heart included in the pericardium of a human embryo of 7.5 mm body length 5. Fig. 532. Development of the heart chambers and septa 6. Fig. 533. Heart of a newborn viewed from the front and placed in the vertical direction 7. Fig. 534. Fetal heart, dorsal half with the afferent paths, open and colored accordin...
Reviews
Végh AMD, Duim SN, Smits AM, Poelmann RE, Ten Harkel ADJ, DeRuiter MC, Goumans MJ & Jongbloed MRM. (2016). Part and Parcel of the Cardiac Autonomic Nerve System: Unravelling Its Cellular Building Blocks during Development. J Cardiovasc Dev Dis , 3, . PMID: 29367572 DOI.
Articles
Cho KH, Kim JH, Murakami G, Abe H, Rodríguez-Vázquez JF & Chai OH. (2019). Nerve distribution in myocardium including the atrial and ventricular septa in late stage human fetuses. Anat Cell Biol , 52, 48-56. PMID: 30984452 DOI. Wu SM, Chien KR & Mummery C. (2008). Origins and fates of cardiovascular progenitor cells. Cell , 132, 537-43. PMID: 18295570 DOI. Person AD, Klewer SE & Runyan RB. (2005). Cell biology of cardiac cushion development. Int. Rev. Cytol. , 243, 287-335. PMID: 15797462 DOI...
Heart 1. angioblastic cords- Groups or ‘columns’ of embryonic precursor cells which will form the walls of both arteries and veins. 1. apex- Anatomical term referring to the most inferior, left, downwards pointing part of the heart. 1. aorta- The largest artery in the human body originating in the left ventricle. The aorta ascends, arches over the ...
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- Primitive Heart Tube. The development of the heart begins with the formation of the primitive heart tube following the folding of the embryo during the end of the third week.
- Atria. At the fourth week, the sinus venosus is responsible for the inflow of blood to the primitive heart, and empties into the primitive atrium. It receives venous blood from the right and left sinus horns.
- Aortic Arches. The early arterial system begins as a bilaterally symmetrical system of arched vessels, which then undergo extensive remodeling to create the major arteries that exit the heart.
- Septation of the Heart. Septation of the heart into right and left channels occurs first, when endocardial cushions developing in the atrioventricular region expand to divide the heart.
Aug 14, 2023 · The first system to develop due to the growing embryo's ever-increasing metabolic demands is the cardiovascular system. Initially, simple diffusion of necessary nutrients is sufficient but eventually becomes inadequate to supply oxygen and nutrients. Cardiac development is a complicated interplay of molecular communication, ensuring the proper formation of structures and spatial configuration ...
The heart is the first functioning organ forming in the embryo; its development entails extensive lineage diversification, cell-fate specification, and tissue patterning. 6–8 The heart originates from the mesoderm, one of the three germ layers established in the developing embryo during the process of gastrulation. Gastrulation occurs during the 3rd week of gestation, when the epiblast, a ...
