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Pharmaceutical companies have developed sophisticated automated processes that screen cancer drugs by testing them on malignant cells—in a dish. The Petri dish has influenced the fundamental direction of much cancer research, in Wirtz's view.
Nov 10, 2023 · Researchers have reprogrammed skin cells to create cardiomyocytes, the cells that enable heart muscle to contract, and have begun using them for dish-based drug screening. In this micrograph of a cardiomyocyte, the orange indicates the protein troponin T, while the blue depicts the nucleus.
Jun 17, 2021 · In a bid to find or refine laboratory research models for cancer that better compare with what happens in living people, Johns Hopkins Medicine scientists report they have developed a new computer-based technique showing that human cancer cells grown in culture dishes are the least genetically similar to their human sources.
Jun 1, 2018 · An alternative approach to modeling cancer in a dish entails reprogramming adult differentiated cells from patients with cancer syndromes to pluripotent stem cells (PSCs), followed by directed differentiation of those PSCs.
- Mo Liu, Jian Tu, Jian Tu, Julian A Gingold, Celine Shuet Lin Kong, Dung-Fang Lee
- Am J Cancer Res. 2018; 8(6): 944-954.
- 2018
- 2018
Jun 11, 2015 · In a highly successful, first-of-its-kind endeavor, a multidisciplinary team of University of Wisconsin–Madison researchers has created a “tumor in a dish:” an ex vivo microenvironment that can accurately anticipate a multiple myeloma patient’s response to a drug.
Jan 11, 2012 · These new findings support the notion that drugs that are currently being tested to treat many cancers need to be screened using more complex tissue-like systems, rather than by using conventional petri dish cultures that do not fully manifest features of many cancers.
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Jan 11, 2012 · New research, using oral cancer cells in a three-dimensional model of lab-made tissue, demonstrates that previous models used to examine cancer may not be complex enough to accurately mimic the...
