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51%
- Up to 51% of cases of FUO, even in the current era, remain undiagnosed. 5 The likelihood of undiagnosed cases may be greater in higher-income regions, an association that is probably due to overrepresentation of patients with “difficult to diagnose” conditions. 7
www.nejm.org/doi/full/10.1056/NEJMra2111003
Feb 2, 2022 · In 1961, Petersdorf and Beeson defined fever of unknown origin (FUO) as a temperature of 38.3°C or higher for at least 3 weeks without a diagnosis, despite 1 week of inpatient investigations....
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- The Three Long-Continued Fevers of New England
It is important to rule out factitious fever, which has been reported in up to 9% of cases. 10 It should be suspected in cases of fever lasting longer than six months and in medical personnel.
Aug 14, 2023 · The causes of fever of unknown origin (FUO) are often common conditions presenting atypically. The list of causes is extensive, and it is broken down into broader categories, such as infection, noninfectious inflammatory conditions, malignancies, and miscellaneous.
- Ilona Brown, Nancy A. Finnigan
- 2023/08/14
- 2021
May 2, 2020 · While FUO subgroups and etiologic classifications have remained unchanged since 1991 revisions, the spectrum of diseases, clinical approach to diagnosis, and management are changing. This review considers how newer data should influence both definitions and lingering dogmatic principles.
- William F Wright, Paul G Auwaerter
- 2020
Nov 28, 2023 · Clinicians commonly refer to a febrile illness without an initially obvious etiology as fever of unknown origin (FUO). However, most febrile illnesses either resolve before a diagnosis can be made or develop distinguishing characteristics that lead to a diagnosis.
Aug 23, 2021 · Prolonged fever of 38.3°C or higher for at least 3 weeks’ duration has been termed fever of unknown origin if unexplained after preliminary investigations. Initially codified in 1961, classification with subgroups was revised in 1991.
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Jul 27, 2024 · Results: The causes of FUO with the highest rates from the 51 identified case series (n = 19,874) were infectious, autoimmune, and neoplastic diseases (59.6%, 14.3%, and 7.9%, respectively).
