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  1. Feb 2, 2022 · In 1961, Petersdorf and Beeson defined fever of unknown origin (FUO) as a temperature of 38.3°C or higher for at least 3 weeks without a diagnosis, despite 1 week of inpatient investigations....

  2. It is important to rule out factitious fever, which has been reported in up to 9% of cases. 10 It should be suspected in cases of fever lasting longer than six months and in medical personnel.

  3. Aug 14, 2023 · The causes of fever of unknown origin (FUO) are often common conditions presenting atypically. The list of causes is extensive, and it is broken down into broader categories, such as infection, noninfectious inflammatory conditions, malignancies, and miscellaneous. Noninfectious Inflammatory Causes of FUO.

    • Ilona Brown, Nancy A. Finnigan
    • 2023/08/14
    • 2021
  4. Fever of unknown origin (FUO) was originally defined by Petersdorf and Beeson as an illness of more than 3 weeks’ duration, with fever greater than 38.3 °C (101 °F) on several occasions, the cause of which is uncertain after 1 week of in-hospital investigations.

  5. Jun 10, 2024 · Classic fever of unknown origin (FUO) was first robustly studied in 1961, with subsequent modifications in definitions (Table 1) [1, 2]. These FUO definitions require an illness of ≥3 weeks duration and temperatures of ≥38.3°C (≥100.9°F) on several occasions [1, 2].

  6. Nov 10, 2024 · Granulomatous diseases (granulomatous hepatitis, Crohn disease, ulcerative colitis) and factitious fever are more likely than infection, cancer, and autoimmune disorders if fever has been present for ≥ 6 months

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  8. In adults, infections (25–40% of cases) and cancer (25–40% of cases) account for the majority of FUOs. In children, infections are the most common cause of FUO (30–50% of cases) and cancer a rare cause (5–10% of cases).

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