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It is important to rule out factitious fever, which has been reported in up to 9% of cases. 10 It should be suspected in cases of fever lasting longer than six months and in medical personnel.
- Roth and Basello
Cunha BA. Fever of unknown origin. Infect Dis Clin North Am....
- AAFP
Fever of unknown origin is defined as a clinically...
- Hersch and Oh
Zenone T. Fever of unknown origin in adults: evaluation of...
- Roth and Basello
Feb 2, 2022 · In 1961, Petersdorf and Beeson defined fever of unknown origin (FUO) as a temperature of 38.3°C or higher for at least 3 weeks without a diagnosis, despite 1 week of inpatient investigations....
Jun 10, 2024 · Classic fever of unknown origin (FUO) was first robustly studied in 1961, with subsequent modifications in definitions (Table 1) [1, 2]. These FUO definitions require an illness of ≥3 weeks duration and temperatures of ≥38.3°C (≥100.9°F) on several occasions [1, 2].
With the development of better diagnostic techniques, the cause of fever is often found before three weeks of illness and therefore only more difficult to diagnose cases meet the definition of FUO. The latest addition to the diagnostic protocol is early FDG-PET/CT, which has a high diagnostic yield.
Fever of unknown origin is defined as a clinically documented temperature of 101°F or higher on several occasions, cou-pled with an unrevealing diagnostic workup. The diferential diagnosis is...
This issue of Case Reports presents two cases of fever of unknown origin (FUO) that illustrate the etiological diversity and diagnostic complexity of this condition. 1, 2. The world literature reports over 200 causes of FUO, including a complex mix of old and emerging diseases, as well as rare and frequent ones.
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In adults, infections (25–40% of cases) and cancer (25–40% of cases) account for the majority of FUOs. In children, infections are the most common cause of FUO (30–50% of cases) and cancer a rare cause (5–10% of cases).
