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  1. Feb 2, 2022 · In 1961, Petersdorf and Beeson defined fever of unknown origin (FUO) as a temperature of 38.3°C or higher for at least 3 weeks without a diagnosis, despite 1 week of inpatient investigations....

  2. It is important to rule out factitious fever, which has been reported in up to 9% of cases. 10 It should be suspected in cases of fever lasting longer than six months and in medical personnel.

  3. Fever of unknown origin (FUO) was originally defined by Petersdorf and Beeson as an illness of more than 3 weeks’ duration, with fever greater than 38.3 °C (101 °F) on several occasions, the cause of which is uncertain after 1 week of in-hospital investigations.

  4. Fever of unknown origin (FUO) is a clinical and diagnostic challenge in routine medical practice and the potential causes of FUO may involve more than 200 diseases [1, 2]. Apart from diarrheal diseases, respiratory infections, and skin lesions, FUO is one of the most common health problems in travelers [ 3 , 4 ].

  5. Aug 14, 2023 · The causes of fever of unknown origin (FUO) are often common conditions presenting atypically. The list of causes is extensive, and it is broken down into broader categories, such as infection, noninfectious inflammatory conditions, malignancies, and miscellaneous. Noninfectious Inflammatory Causes of FUO.

    • Ilona Brown, Nancy A. Finnigan
    • 2023/08/14
    • 2021
  6. Jun 10, 2024 · Classic fever of unknown origin (FUO) was first robustly studied in 1961, with subsequent modifications in definitions [1, 2]. These FUO definitions require an illness of ≥3 weeks duration and temperatures of ≥38.3°C (≥100.9°F) on several occasions [1, 2].

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  8. Aug 23, 2021 · Prolonged fever of 38.3°C or higher for at least 3 weeks’ duration has been termed fever of unknown origin if unexplained after preliminary investigations. Initially codified in 1961, classification with subgroups was revised in 1991.

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