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Sep 14, 2022 · The basement membrane is formed by a mixture of molecules, including type IV collagen (i.e., the structural protein found in the basement membrane, the lens of the eye, and the cochlea of the ear) primarily and laminin (i.e., a glycoprotein, or protein that contains oligosaccharide chains). Several other proteins, like nidogen and perlecan, can ...
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The basement membrane, also known as base membrane, is a thin, pliable sheet-like type of extracellular matrix that provides cell and tissue support and acts as a platform for complex signalling. [1][2] The basement membrane sits between epithelial tissues including mesothelium and endothelium, and the underlying connective tissue. [3][4]
Oct 30, 2023 · The basement membrane is a thin, non-cellular, extracellular protein matrix that forms a specialized supporting sheet directly beneath the basal surfaces of all epithelial cells, separating them from underlying supporting tissues. In non-epithelial cells such as muscle, adipocytes and nervous tissue, the basement membrane is typically referred ...
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The basement membrane is a thin but dense, sheet-like specialized type of extracellular matrix that has remarkably diverse functions tailored to individual tissues and organs. Tightly controlled spatial and temporal changes in its composition and structure contribute to the diversity of basement membrane functions.
Feb 17, 2021 · 1. Introduction. Tissues must be of the correct size and shape in order to carry out their normal function. The basement membrane (BM) is a special type of extracellular matrix that lines the basal side of epithelial and endothelial cells and is important for the form and function of the overlying tissues.
- Nargess Khalilgharibi, Yanlan Mao
- 2021
Mar 20, 2017 · Summary. Basement membranes (BMs) are thin, dense sheets of specialized, self-assembled extracellular matrix that surround most animal tissues (Figure 1, top). The emergence of BMs coincided with the origin of multicellularity in animals, suggesting that they were essential for the formation of tissues. Their sheet-like structure derives from ...
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Sep 16, 2020 · Topographical organization of the basement membrane. The BM possesses topographical features at different scales. (A) At the larger scale, BM topography takes the form of undulations. Images reproduced from Kawabe et al. (1985) (left) and Li et al. (2012) (right) with permission from Wiley. (B) At the micron scale, BM topography takes the form ...
