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- The exact cause of AERD is not known but it is not an allergic response. There is no proof to show that it's genetic or inherited. The disease is not caused by taking aspirin or NSAIDs, but AERD sinus or asthma symptoms get worse when taking these medicines.
www.mayoclinic.org/diseases-conditions/asthma/in-depth/aerd/art-20482797
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Mar 28, 2023 · The exact cause of AERD is not known but it is not an allergic response. There is no proof to show that it's genetic or inherited. The disease is not caused by taking aspirin or NSAIDs, but AERD sinus or asthma symptoms get worse when taking these medicines.
Genetic disorders occur when a mutation affects your genes or chromosomes. Some disorders cause symptoms at birth, while others develop over time. Genetic testing can help you learn more about the likelihood of experiencing a genetic disorder.
Aspirin-exacerbated respiratory disease (AERD), also called NSAID-exacerbated respiratory disease (N-ERD) or historically aspirin-induced asthma and Samter's Triad, is a long-term disease defined by three simultaneous symptoms: asthma, chronic rhinosinusitis with nasal polyps, and intolerance of aspirin and other nonsteroidal anti-inflammatory d...
Aug 19, 2021 · Many rare lung diseases are genetic disorders. Babies are born with disease-causing changes encoded in their genes. But some diseases may not develop until later in life.
Jul 1, 2019 · Several genetic studies on aspirin hypersensitivity have been performed to detect the genetic predisposition to AERD and to gain insight into the phenotypic diversity. 20, 21, 22 However, familial AERD is rare, 3 and no strong genetic basis has been observed.
- Masami Taniguchi, Chihiro Mitsui, Hiroaki Hayashi, Emiko Ono, Keiichi Kajiwara, Haruhisa Mita, Kenta...
- 2019
Oct 16, 2023 · We suggest, in line with Stevens and Cahill, 2 that AERD is a chronic respiratory disease characterized by asthma and rhinosinusitis with recurrent nasal polyps and intolerance to nonspecific COX inhibitors, regardless of the cellular inflammatory endotype of asthma (Table I). 3 Chronic rhinosinusitis with nasal polyps in AERD is difficult to tr...
Feb 6, 2023 · Works published in 2021-2022 confirmed the critical role of lipid mediator dysregulation and mast cell activation and expanded our understanding of basophils, macrophages, fibrin dysregulation, and the 15-lipoxygenase pathway in disease pathogenesis.
