Search results
Biological plausibility is one component of a method of reasoning that can establish a cause-and-effect relationship between a biological factor and a particular disease or adverse event. It is also an important part of the process of evaluating whether a proposed therapy (drug, vaccine, surgical procedure, etc.) has a real benefit to a patient.
Nov 16, 2020 · A search of ‘biologically plausible' on Google scholar returns 103 000 hits. Biological plausibility is something the field strives toward and prizes. Unfortunately, it is not clear that the claim of biological plausibility has content or is coherent, particularly in the context of multi-level theorizing.
- Bradley C. Love
- 2021
Jan 16, 2022 · The criterion reflects the pre-existing theory and knowledge (the “Coherence” of other authors [11, 23]) and is interpreted broadly, including the following elements of coherence: (1) with theoretical plausibility (also named in ), (2) with facts, (3) with biological knowledge (i.e., “Biological Plausibility”), and (4) with statistical patterns including the dose–effect relationship ...
Hill’s criterion of plausibility is satisfied if the relationship is consistent with the current body of knowledge regarding the etiology and mechanism of disease; though, Hill admitted that this interpretation of biological plausibility was dependent on the current state of knowledge. Today, tools such as high-throughput screening assays can be used to study a specific biologically ...
Apr 1, 2022 · As a concept, biological plausibility was first formalised in 1965 by Sir Austin Bradford Hill, as one of his considerations for establishing causality (Hill, 1965). Bradford Hill argued that the presence of biological plausibility can increase the likelihood that a relationship between an exposure and a health outcome is a causal one.
Feb 24, 2022 · “Biological plausibility” is a concept frequently referred to in environmental and public health when researchers are evaluating how confident they are in the results and inferences of a study or evidence review. Biological plausibility is not, however, a domain of one of the most widely used approaches for assessing the certainty of evidence (CoE) which underpins the findings of a ...
People also ask
Is biological plausibility coherent?
What is biological plausibility?
How many levels of biological plausibility and coherence are there?
Do we need a “biological plausibility” criterion?
Does 'plausibility' really matter if a causation is biologically plausible?
What is the causality criterion 'biological plausibility'?
Jan 4, 2021 · Claims of biological plausibility are shown to be incoherent from a level of mechanism view and more generally are vacuous. ... or is coherent, ... would be very strange to attack a high-level ...
