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1. www.nature.com › articles › s41467/017/01757-0Origin of the omnipotence of eukaryotic release factor 1 - Nature

   www.nature.com › articles › s41467/017/01757-0

   Nov 10, 2017 · The eukaryotic release factor eRF1 is able to recognize the three stop codons UAA, UAG and UGA with high accuracy, while discriminating against near-cognate codons.

   • Author: Christoffer Lind, Ana Oliveira, Johan Åqvist

   • Publish Year: 2017

2. www.ncbi.nlm.nih.gov › pmc › articlesEnzymes: principles and biotechnological applications - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 11, 2015 · In terms of energetics, reactions can be either exergonic (releasing energy) or endergonic (consuming energy). However, even in an exergonic reaction a small amount of energy, termed the activation energy, is needed to give the reaction a ‘kick start.’

   • Author: Peter K. Robinson
   • DOI: 10.1042/bse0590001

   • Publish Year: 2015
   • Publication: Essays Biochem. 2015 Nov 15; 59: 1-41.

3. www.ncbi.nlm.nih.gov › pmc › articlesDistinct Roles for Release Factor 1 and Release Factor 2 in ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Jun 6, 2014 · Results: Release factor 2 preferentially recognizes mismatched ribosomal complexes. Conclusion: Release factor 1 and release factor 2 have evolved to carry out distinct functions beyond canonical termination. Significance: Release factor 2 is a key translational quality control factor in bacteria.

   • Author: Alexandros D. Petropoulos, Megan E. McDonald, Rachel Green, Hani S. Zaher
   • DOI: 10.1074/jbc.M114.564989

   • Publish Year: 2014
   • Published: 2014/06/06

4. en.wikipedia.org › wiki › Release_factorRelease factor - Wikipedia

   en.wikipedia.org › wiki › Release_factor

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   A release factor is a protein that allows for the termination of translation by recognizing the termination codon or stop codon in an mRNA sequence. They are named so because they release new peptides from the ribosome.

5. www.ncbi.nlm.nih.gov › pmc › articlesThe Origin and Evolution of Release Factors: Implications for ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Apr 23, 2019 · The evolution of release factors catalyzing the hydrolysis of the final peptidyl-tRNA bond and the release of the polypeptide from the ribosome has been a longstanding paradox.

   • Author: A. Maxwell Burroughs, L Aravind
   • DOI: 10.3390/ijms20081981

   • Publish Year: 2019
   • Publication: Int J Mol Sci. 2019 Apr; 20(8): 1981.

6. bio.libretexts.org › Bookshelves › Introductory_and8.6: Enzymes - Biology LibreTexts

   bio.libretexts.org › Bookshelves › Introductory_and

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   On a basic level, enzymes promote chemical reactions that involve more than one substrate by bringing the substrates together in an optimal orientation for reaction. Enzymes promote the reaction of their substrates by creating an optimal environment within the active site for the reaction to occur.

7. People also ask

   What is a release factor?

   • A release factor is a protein that allows for the termination of translation by recognizing the termination codon or stop codon in an mRNA sequence. They are named so because they release new peptides from the ribosome.

   Release factor - Wikipedia

   en.wikipedia.org/wiki/Release_factor

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   What is release factor 2?

   • Significance: Release factor 2 is a key translational quality control factor in bacteria. Keywords: Protein Synthesis, Ribosome, Translation, Translation Control, Translation Release Factor In bacteria, stop codons are recognized by two similar class 1 release factors, release factor 1 (RF1) and release factor 2 (RF2).

   Distinct Roles for Release Factor 1 and Release Factor 2 in Translational …

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4067194/

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   What is a Class 1 release factor?

   • Class 1 release factors recognize stop codons; they bind to the A site of the ribosome in a way mimicking that of tRNA, releasing the new polypeptide as it disassembles the ribosome. [ 3][ 4] Class 2 release factors are GTPases that enhance the activity of class 1 release factors. It helps the class 1 RF dissociate from the ribosome. [ 5]

   Release factor - Wikipedia

   en.wikipedia.org/wiki/Release_factor

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   Is eukaryotic release factor 3 required for multiple turnovers of peptide release catalysis?

   • Eyler D. E., Wehner K. A., Green R. (2013) Eukaryotic release factor 3 is required for multiple turnovers of peptide release catalysis by eukaryotic release factor 1. J. Biol. Chem. 288, 29530–29538 [ PMC free article] [ PubMed] [ Google Scholar]

   Distinct Roles for Release Factor 1 and Release Factor 2 in Translational …

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4067194/

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   Does ribosome induce a closed to open conformational change in release factor 1?

   • Elife 6, e14874 (2017). Trappl, K. & Joseph, S. Ribosome induces a closed to open conformational change in release factor 1. J. Mol. Biol. 428, 1333–1344 (2016).

   Origin of the omnipotence of eukaryotic release factor 1

   www.nature.com/articles/s41467-017-01757-0

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   Can release factors be deployed beyond conventional translation termination?

   • The genomic contexts and experimental evidence hint at a diversity of contexts in which such release factors might be deployed beyond conventional translation termination.

   The Origin and Evolution of Release Factors: Implications for Translatio…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC6514570/

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8. www.nature.com › articles › s41398/021/01497-2Corticotropin-releasing factor induces functional and ...

   www.nature.com › articles › s41398/021/01497-2

   Jul 7, 2021 · Corticotropin-releasing factor (CRF) plays a central role in regulating these lifesaving physiological responses to stress. We show that, in mice, CRF rapidly changes Schaffer Collateral (SC)...