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Research Administrator · Self-motivated and detail-oriented biologist with a solid training background in Neuroscience, Genomics, Cell Biology, and Regeneration. Demonstrated ability to work both...
- 229
- 240
- University of Michigan
We developed a high-precision, high-fidelity Cas13d variant, hpCas13d, with single nucleo-tide variant resolution and low collateral cleavage activity. RNA editing with hpCas13d is an effective and safe approach for preventing and treating hypertro-phic cardiomyopathy (HCM) in 2 new HCM mouse models.
May 16, 2024 · Abstract. Background: Familial hypertrophic cardiomyopathy has severe clinical complications of heart failure, arrhythmia, and sudden cardiac death. Heterozygous single nucleotide variants (SNVs) of sarcomere genes such as MYH7 are the leading cause of this type of disease.
Jun 14, 2023 · NMD is a translation-dependent mRNA quality surveillance mechanism that prevents the accumulation of potentially deleterious truncated proteins produced by PTC, regulated by Upf1, Upf2, and Upf3 proteins.
- 10.3390/biom13060988
- 2023/06
- Biomolecules. 2023 Jun; 13(6): 988.
May 16, 2024 · To uncover the effect of mismatch location on allelic discrimination, we used the molecular dynamic (MD) model to calculate the root mean square fluctuation (the average fluctuation of the RNA duplex) of each nucleotide in gRNA and in target RNA complexed with wtCas13d and Cas13d variants.
Allele-Specific Suppression of Variant MHC With High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy. Ping Yang, Yingmei Lou, Zilong Geng, Zhizhao Guo, Shuo Wu, Yige Li, Kaiyuan Song, Ting Shi, Shasha Zhang, Junhao Xiong, Alex F Chen, Dali Li, William T Pu, Lintai Da, Yan Zhang, Kun Sun, Bing Zhang
Shasha ZHANG, Professor (Assistant) | Cited by 165 | of Shanghai Jiao Tong University, Shanghai (SJTU) | Read 18 publications | Contact Shasha ZHANG
