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First described in 1972, mixed connective tissue disease (MCTD) is an autoimmune disease that is considered to be an overlap of different inflammatory forms of autoimmune connective tissue diseases: systemic lupus erythematosus (lupus), scleroderma, Sjogren’s syndrome and inflammatory myositis (dermatomyositis and polymyositis).
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Early indications of mixed connective tissue disease can include:
•General feeling of being unwell. This can include increased fatigue and a mild fever.
•Cold and numb fingers or toes (Raynaud's phenomenon). In response to cold or stress, your fingers or toes might turn white and then purplish blue. After warming, the fingers or toes turn red.
•Swollen fingers or hands. Some people have swelling of the fingers.
•Muscle and joint pain. Joints can become inflamed, swollen and deformed, similar to what occurs with rheumatoid arthritis.
•Rash. Red or reddish brown patches can appear over the knuckles.
See your doctor if you have signs and symptoms that interfere with your daily routine — particularly if you've been diagnosed with lupus or another connective tissue disease.
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Mixed connective tissue disease is an autoimmune disorder, although the cause isn't known. In autoimmune disorders, your immune system — responsible for fighting off disease — mistakenly attacks healthy cells.
In connective tissue diseases, your immune system attacks the fibers that provide the framework and support for your body. Some people with mixed connective tissue disease have a family history of the condition. But the role of genetics in the disease remains unclear.
Mixed connective tissue disease can occur in people of any age. However, it appears to be most common in women under the age of 50.
Mixed connective tissue disease can lead to serious complications, some of which can be fatal. Complications include:
•High blood pressure in the lungs (pulmonary hypertension). This condition is a major cause of death in people with mixed connective tissue disease.
•Interstitial lung disease. This large group of disorders can cause scarring in your lungs, which affects your ability to breathe.
•Heart disease. Parts of the heart can enlarge, or inflammation can occur around the heart. Heart failure can occur.
•Kidney damage. About one-fourth of people with mixed connective tissue disease develop kidney problems, Kidney involvement is usually mild, but can lead to kidney failure.
•Digestive tract damage. Commonly, mixed connective tissue disease affects the digestive tract. You might have abdominal pain and problems with swallowing and digesting food.
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Apr 27, 2020 · Degenerative joint disease, or osteoarthritis, is the most common type of arthritis. While this condition can occur in any joint, it usually affects the hands, knees, hips or spine. This disease is common because wear and tear on the joints over time can cause cartilage to break down.
Feb 18, 2023 · In this review, we explore the cellular and molecular crosstalk established between the major joint compartments—the synovial membrane, cartilage, and subchondral bone of normal and OA-affected joints. The synovial joints represent the most common type of joint in the human body [ 45 ].
In autoimmune disorders, inflammation and the immune response may result in connective tissue damage, not only in and around joints but also in other tissues, including vital organs, such as the kidneys and organs in the gastrointestinal tract.
Apr 23, 2020 · A pathological triad of inter-related disorders that are highly prevalent in elderly subjects consists of the following main “components”: sarcopenia, tendinopathies, and arthritis (the acronym “STAR” will be henceforth adopted).
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Aug 4, 2021 · By further describing the physiological environment of the joint and its pathological alterations after trauma, we discuss the consequent changes in EVs and their potential as a diagnostic tool to identify joint diseases.
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related to: v celluloid joint diseaseXIAFLEX® (collagenase clostridium histolyticum). See PI Incl. Boxed Warning & Safety Info. Learn More Today About A Treatment Option Near You.
