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  1. May 27, 2023 · Having too much cholesterol in the blood increases the risk of heart attacks and strokes. Statins block an enzyme the liver needs to make cholesterol. This causes the liver to remove cholesterol from the blood. While statins are highly effective and safe for most people, they have been linked to muscle pain, digestive problems and mental ...

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    Early indications of mixed connective tissue disease can include:

    •General feeling of being unwell. This can include increased fatigue and a mild fever.

    •Cold and numb fingers or toes (Raynaud's phenomenon). In response to cold or stress, your fingers or toes might turn white and then purplish blue. After warming, the fingers or toes turn red.

    •Swollen fingers or hands. Some people have swelling of the fingers.

    •Muscle and joint pain. Joints can become inflamed, swollen and deformed, similar to what occurs with rheumatoid arthritis.

    •Rash. Red or reddish brown patches can appear over the knuckles.

    See your doctor if you have signs and symptoms that interfere with your daily routine — particularly if you've been diagnosed with lupus or another connective tissue disease.

    Request an appointment

    Mixed connective tissue disease is an autoimmune disorder, although the cause isn't known. In autoimmune disorders, your immune system — responsible for fighting off disease — mistakenly attacks healthy cells.

    In connective tissue diseases, your immune system attacks the fibers that provide the framework and support for your body. Some people with mixed connective tissue disease have a family history of the condition. But the role of genetics in the disease remains unclear.

    Mixed connective tissue disease can occur in people of any age. However, it appears to be most common in women under the age of 50.

    Mixed connective tissue disease can lead to serious complications, some of which can be fatal. Complications include:

    •High blood pressure in the lungs (pulmonary hypertension). This condition is a major cause of death in people with mixed connective tissue disease.

    •Interstitial lung disease. This large group of disorders can cause scarring in your lungs, which affects your ability to breathe.

    •Heart disease. Parts of the heart can enlarge, or inflammation can occur around the heart. Heart failure can occur.

    •Kidney damage. About one-fourth of people with mixed connective tissue disease develop kidney problems, Kidney involvement is usually mild, but can lead to kidney failure.

    •Digestive tract damage. Commonly, mixed connective tissue disease affects the digestive tract. You might have abdominal pain and problems with swallowing and digesting food.

    •A Book: Mayo Clinic Family Health Book, 5th Edition

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  2. Aug 29, 2023 · Rheumatoid arthritis is a disease in which the immune system attacks the joints, beginning with the lining of joints. Arthritis is the swelling and tenderness of one or more joints. The main symptoms of arthritis are joint pain and stiffness, which typically worsen with age. The most common types of arthritis are osteoarthritis and rheumatoid ...

  3. Oct 11, 2022 · ROCHESTER, Minn. — For joints to work well, they need cartilage, a slippery tissue that covers the ends of bones, acts like a shock absorber, and helps joints move smoothly. Joaquin Sanchez-Sotelo, M.D., Ph.D., a Mayo Clinic orthopedic surgeon, says many people lose cartilage as they age, but it does not mean that joint replacement is inevitable.

  4. RA increases the risk of serious infection, including infections that require hospitalization, making it difficult to determine to what extent biologics may increase the risk. Age, other health problems and other medications can also increase the risk of certain side effects. Studies show that having diabetes, chronic lung disease or taking ...

  5. Bisphosphonates are widely prescribed and highly effective at limiting the bone loss that occurs in many disorders characterized by increased osteoclast-mediated bone resorption, including senile osteoporosis in both men and women, glucocorticoid-associated osteoporosis, and malignancies metastatic to bone. Although they are generally well tolerated, potential adverse effects may limit ...

  6. Jun 2, 2022 · ANSWER: Collagen and biotin supplements are promoted for healthy aging, along with joint and bone health. However, it is important to understand what collagen and biotin are and what research is available to support these claims. Collagen is concentrated in bones, ligaments, tendons, skin, blood vessels and internal organs.

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