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Environmental factors, such as exposure to radiation or harmful chemicals, cause others. Sometimes, people may inherit genetic tendencies that make their cells more prone to rearrangements. However, most rearrangements that occur in cancer are not inherited but develop over time in specific cells, known as somatic rearrangements.
Dec 30, 2022 · 16.9: DNA Rearrangement is shared under a not declared license and was authored, remixed, and/or curated by LibreTexts. One of the central assumptions throughout our study of the cell has been that although the RNA and proteins in any cell may differ, any cell of a given organism other than the gametes should have the ….
DNA Rearrangements. Homologous recombination results in the reassortment of genes between chromosome pairs without altering the arrangement of genes within the genome. In contrast, other types of recombinational events lead to rearrangements of genomic DNA. Some of these DNA rearrangements are important in controlling gene expression in ...
- Geoffrey M Cooper
- 2000
Chromosomal Rearrangements. A chromosomal rearrangement means that pieces of chromosomes are missing, duplicated (there are extra copies), or moved around. The effects vary. They depend on which chromosome pieces are involved and how they are rearranged. Some have no effect, some are incompatible with life, and others are somewhere between.
Shortly after the discovery of chromothripsis, sequencing efforts to characterize somatic DNA alterations in prostate cancer genomes unexpectedly identified a class of chained rearrangements called chromoplexy [31]. In contrast to chromothripsis in which relatively few chromosomes are affected, chromoplexy describes an intricate series of loop-like rearrangements that seemingly connects ...
Feb 28, 2021 · Not all structural rearrangements of chromosomes produce nonviable, impaired, or infertile individuals. In rare instances, such a change can result in the evolution of a new species. In fact, a pericentric inversion in chromosome 18 appears to have contributed to the evolution of humans. This inversion is not present in our closest genetic ...
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In a population, this type of genetic variation is crucial to allow organisms to evolve in response to a changing environment. The DNA rearrangements are caused by a set of mechanisms that are collectively called genetic recombination. Two broad classes are commonly recognized—general recombination and site-specific recombination. In this ...
