Search results
Feb 6, 2020 · A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments that range in size from kilobases to whole chromosomes 1,2,3,4,5,6,7 ...
- Yilong Li, Nicola D Roberts, Jeremiah A Wala, Jeremiah A Wala, Ofer Shapira, Ofer Shapira, Steven E ...
- 2020
Abstract. Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. The most frequent type based on large-scale DNA sequencing of human tumors is chromothripsis, a massive, localized and clustered rearrangement of one (or a few) chromosomes seemingly acquired in a single event.
Such rearrangements have the potential to cause cancer if they mutate a tumor suppressor gene or activate an oncogene 2 and can also contribute to tumor heterogeneity and clonal evolution as mechanisms for metastasis and drug resistance. 3, 4 Thus, chromosomal rearrangements are important in cancer etiology. This review will first describe recent advancements in technologies that drove the ...
Nov 8, 2023 · Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of complex chromosome ...
Jan 29, 2024 · Genomic rearrangements, also called structural variants, are a key source of somatic mutations in human cancer 21, 107. Although some of these structural variants are interlinked and share ...
Sep 9, 2021 · The identification of large chromosomal rearrangements in cancers has multiplied exponentially over the last decade. These complex and often rare genomic events have traditionally been challenging to study, in part owing to lack of tools that efficiently engineer disease-associated inversions, deletions and translocations in model systems.
People also ask
What is complex chromosome rearrangement?
Are complex chromosome rearrangements common in cancer?
Are chromosome rearrangements a cancer driver?
What is the role of rearrangement in cancer?
Are cancer genomes rearranged?
Why are cancer rearrangements grouped into clusters?
Because a [1,5] sigmatropic rearrangement involves three electron pairs (two π bonds and one σ bond), the orbital-symmetry rules in Table 30.3 predict a suprafacial reaction. In fact, the [1,5] suprafacial shift of a hydrogen atom across two double bonds of a π system is a commonly observed sigmatropic rearrangements. For example, 5-methyl-1 ...
