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  1. Fever of unknown origin (FUO) was originally defined by Petersdorf and Beeson as an illness of more than 3 weeks’ duration, with fever greater than 38.3 °C (101 °F) on several occasions, the cause of which is uncertain after 1 week of in-hospital investigations.

  2. Jul 9, 2024 · Miscellaneous (15 to 25%) Infections are the most common cause of FUO. In patients with HIV infection, opportunistic infections (eg, tuberculosis; infection by atypical mycobacteria, disseminated fungi, or cytomegalovirus) should be sought.

    • Larry M. Bush
  3. Aug 14, 2023 · The causes of fever of unknown origin (FUO) are often common conditions presenting atypically. The list of causes is extensive, and it is broken down into broader categories, such as infection, noninfectious inflammatory conditions, malignancies, and miscellaneous.

    • Ilona Brown, Nancy A. Finnigan
    • 2023/08/14
    • 2021
  4. Common causes of FUO include infections, malignancies, noninfectious inflammatory disease (e.g., vasculitides, granulomatous disease, connective tissue diseases), miscellaneous, and...

  5. Feb 2, 2022 · The major causes of classic FUO are infections, cancers, autoinflammatory or autoimmune conditions, and miscellaneous causes. 3 A review of all infections causing FUO is not possible...

  6. Jun 17, 2015 · Because fever of unknown origin may be caused by over 200 malignant/neoplastic, infectious, rheumatic/inflammatory, and miscellaneous disorders, clinicians often order non-clue-based imaging and specific testing early in the fever of unknown origin work-up, which may be inefficient/misleading.

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  8. A variety of bacterial infections can cause FUO, and these can be divided into those that are easy to identify using culture and those that require serological or molecular tests for identification. A number of viral, parasitic and fungal infections can also cause prolonged fever.

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