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Synthetic gene regulatory circuits have been made that can generate unique and desired outcomes. Can synthetic metabolic circuits be made to accomplish similar outcomes for gene expression? Feedback repression provides gene regulation with the ability to adapt to variable metabolic conditions.
Feb 7, 2013 · Here we review the diverse mechanisms cells use to adapt metabolism to specific physiological states and discuss how metabolic flux analyses can be applied to identify important regulatory nodes to understand normal and pathological cell physiology.
- Christian M. Metallo, Matthew G. Vander Heiden, Matthew G. Vander Heiden
- 2013
Sep 22, 2024 · Embryonic cells differentiate as the embryo develops. Even after terminal differentiation of cells that form all adult tissues and organs, adult stem cells will divide and differentiate to replace worn out cells. Once differentiated, cells are typically signaled in G1 to enter G0 and stop cycling.
The first rule is that “all living organisms are made of cells“, the second is that “the cell is the smallest structural and functional biological unit that constitutes a living organism”, and the third is that “every cell is derived from another cell” .
Apr 11, 2019 · We highlight the regulation of glucose uptake, amino acid acquisition and lipid and nucleotide synthesis during homeostatic cell proliferation and then consider how cells maintain growth in...
- Jiajun Zhu, Craig B. Thompson
- 2019
Mar 17, 2022 · Gene expression in prokaryotes is regulated only at the transcriptional level, whereas in eukaryotic cells, gene expression is regulated at the epigenetic, transcriptional, post-transcriptional, translational, and post-translational levels.
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Jan 23, 2020 · In brief, perturbations of anaerobic glycolysis, fatty acid synthesis, fatty acid oxidation, glutaminolysis, or mitochondrial oxidative phosphorylation have been increasingly used to understand how metabolism is coupled to the function of T cells, macrophages, and natural killer (NK) cells.
