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Analysis procedures in a method-comparison study include the visual examination of data patterns with graphs and quantification of the estimate of the difference between methods and the precision of that difference, often referred to as bias and precision statistics (Definitions of terms used in method-comparison studies are provided in the table.). If the differences between methods are ...
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In 1919, Dr. George Dock, chairman of the Department of Medicine at Barnes Hospital in St. Louis, asked all of the third- and fourth-year medical students at the teaching hospital to observe an autopsy of a man with a disease so rare, he claimed, that most of the students would likely never see another case of it in their careers. With the medical ...
Beginning in the 1950s, several well-controlled comparative studies were initiated. In 1950, Ernest Wynder and Evarts Graham published a retrospective study comparing the smoking habits of 605 hospital patients with lung cancer to 780 hospital patients with other diseases (Wynder & Graham, 1950). Their study showed that 1.3% of lung cancer patients...
Wynder and Graham also suggested that there might be a lag of ten years or more between the period of smoking in an individual and the onset of clinical symptoms of cancer. This would present a major challenge to researchers since any study that investigated the relationship between smoking and lung cancer in a prospective fashion would have to las...
Richard Doll and Austin Hill published a similar comparative study in 1950 in which they showed that there was a statistically higher incidence of smoking among lung cancer patients compared to patients with other diseases (Doll & Hill, 1950). In their discussion, Doll and Hill raise an interesting point regarding comparative research methods by sa...
They go on to assert that because the habit of smoking was seen to develop before the onset of lung cancer, the argument that lung cancer leads to smoking can be rejected. They therefore conclude, \"that smoking is a factor, and an important factor, in the production of carcinoma of the lung.\"
Despite this substantial evidence, both the tobacco industry and unbiased scientists raised objections, claiming that the retrospective research on smoking was \"limited, inconclusive, and controversial.\" The industry stated that the studies published did not demonstrate cause and effect, but rather a spurious association between two variables. Dr...
While the scientific research began to impact health officials and some legislators, the industry's ad campaign was effective. The US Federal Trade Commission banned tobacco companies from making health claims about their products in 1955. However, more significant regulation was averted. An editorial that appeared in the New York Times in 1963 sum...
In 1951, Doll and Hill enrolled 40,000 British physicians in a prospective comparative study to examine the association between smoking and the development of lung cancer. In contrast to the retrospective studies that followed patients with lung cancer back in time, the prospective study was designed to follow the group forward in time. In 1952, Dr...
All of the studies demonstrated that smokers are at a higher risk of developing and dying from lung cancer than nonsmokers. The ACS study further showed that smokers have elevated rates of other pulmonary diseases, coronary artery disease, stroke, and cardiovascular problems. The two ACS Cancer Prevention Studies would eventually show that 52% of d...
In the second half of the 20th century, evidence from other scientific research methods would contribute multiple lines of evidence to the conclusion that cigarette smoke is a major cause of lung cancer: As evidence linking cigarette smoke to lung cancer and other diseases accumulated, the public, the legal community, and regulators slowly responde...
Jun 29, 2020 · All these data are necessary in order to identify the types of changes. As mentioned above, for the comparison of biological taxonomies we are considering the methods surveyed by Graham & Kennedy (2010) for the comparison of two hierarchies, namely, edge drawing, matrix, animation and agglomeration.
- Lilliana Sancho-Chavarria, Fabian Beck, Erick Mata-Montero
- 10.7717/peerj-cs.277
- 2020
- PeerJ Comput Sci. 2020; 6: e277.
Feb 9, 2018 · Comparative method is a process of analysing differences and/or similarities betwee two or more objects and/or subjects. Comparative studies are based on research techniques and strategies for drawing inferences about causation and/or association of factors that are similar or different between two or more subjects/objects.
Sep 1, 2002 · Comparative studies in biology use an investigative philosophy that many scientists identify as the “comparative method.”. In one sense, for those concerned with evolutionary history, the comparative method provides insights into adaptation by correlating differences among species with ecological factors (Futuyma 1986).
- Glenn M. Sanford, William I. Lutterschmidt, Victor H. Hutchison
- 2002
Apr 1, 2002 · Therefore, gene order correlates with evolutionary distance between genomes to a degree. Study of gene order has been done in various genome comparisons, including the comparison of two strains of H. pylori [26], yeast [30], two mycoplasm genomes [31], Escherichia coli vs. H. influenzae [32], and various prokaryotic genomes [33]. These studies ...
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Aa Aa Aa. Comparative genomics is a field of biological research in which the genome sequences of different species — human, mouse, and a wide variety of other organisms from bacteria to ...
