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The membrane depolarization at the synaptic cleft triggers nearby voltage-gated sodium channels to open. Sodium ions enter the muscle fiber further depolarizing the membrane, and an action potential rapidly spreads (or “fires”) along the entire membrane to initiate excitation-contraction coupling.
- Lindsay M. Biga, Sierra Dawson, Amy Harwell, Robin Hopkins, Joel Kaufmann, Mike LeMaster, Philip Mat...
- 2019
During embryogenesis, skeletal muscle forms in the vertebrate limb from progenitor cells originating in the somites. These cells delaminate from the hypaxial edge of the dorsal part of the somite, the dermomyotome, and migrate into the limb bud, ...
Myogenesis during embryonic and fetal phases is involved in the process of muscle development. During primary myogenesis, skeletal muscle progenitor myoblasts are formed after the differentiation of epiblast, mesoderm progenitor, presomitic progenitor, and aPSM‐dermomyotomal progenitor cells.
The axial muscles derive from the pre-otic somites, are located in the neck, and move the head. The laryngoglossal muscles derive from the pre-otic somites and branchial arch (BA) mesoderm and contribute to the movement of the muscles of larynx, mouth and tongue.
- Hung Ping Shih, Michael K. Gross, Chrissa Kioussi
- 10.1016/j.acthis.2007.08.004
- 2008
- 2008
Oct 4, 2019 · A muscle cell, known technically as a myocyte, is a specialized animal cell which can shorten its length using a series of motor proteins specially arranged within the cell. While several associated proteins help, actin and myosin form thick and thin filaments which slide past each other to contract small units of a muscle cell.
The myotome cells producing the myogenic bHLH proteins are the myoblasts—committed muscle cell precursors. Experiments with chimeric mice and cultured myoblasts showed conclusively that these cells align together and fuse to form the multinucleated myotubes characteristic of muscle tissue.
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The muscle cell, or myocyte, develops from myoblasts derived from the mesoderm. Myocytes and their numbers remain relatively constant throughout life. Skeletal muscle tissue is arranged in bundles surrounded by connective tissue.
