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      • The Biological Classification of Mental Disorders (BeCOME) study aims to identify biology-based classes of mental disorders that improve the translation of novel biomedical findings into tailored clinical applications.
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  2. May 11, 2020 · The Biological Classification of Mental Disorders (BeCOME) study aims to identify biology-based classes of mental disorders that improve the translation of novel biomedical findings into tailored clinical applications.

    • Tanja M. Brückl, Victor I. Spoormaker, Philipp G. Sämann, Anna-Katherine Brem, Anna-Katherine Brem, ...
    • 2020
  3. May 11, 2020 · A major research finding in the field of Biological Psychiatry is that symptom-based categories of mental disorders map poorly onto dysfunctions in brain circuits or neurobiological pathways.

  4. The Biological Classification of Mental Disorders (BeCOME) study aims to identify biology-based classes of mental disorders that improve the translation of novel biomedical findings into tailored clinical applications.MethodsBeCOME intends to include at least 1000 individuals with a broad spectrum of affective, anxiety and stress-related mental ...

  5. "BeCOME" stands for “Biological Classification of Mental Disorders”. Our aim is to improve the classification of mental disorders on the basis of biological features, in order to optimize treatment allocation i.e., optimized stratification for the benefit of the patients.

    • 1 Research Domain Criteria
    • 2 Network Theories of Mental Disorders
    • 3 The New Mechanism
    • Summary and Outlook

    The RDoC initiative was launched in 2009, at the world’s largest psychiatric research institute, the NIMH (National Institute of Mental Health) in Bethesda (Insel 2013; Kozak and Cuthbert 2016). Briefly, the issue was this (adapted from Walter 2017): Thomas Insel, then director of the NIMH, himself a researcher in the field of social neurobiology (...

    Another theory that has been discussed in recent years, not coincidentally, is the network theory of mental disorders (Borsboom 2017; Borsboom et al. 2019). It opposes the essentialist notion that mental health symptoms are “surface features” of an underlying pathological process, as in other diseases. Measles, for example, is clinically manifested...

    We have introduced two approaches that are in principle complementary to each other: While RDoC starts from basic neurocognitive processes and their brain circuits and neglects the level of symptoms, network theories focus on the symptom level and declare the underlying processes negligible. What both approaches have in common is that they want to ...

    In the present chapter we have seen how difficult it is to define, diagnose and distinguish mental disorders from neurological diseases, life problems and from each other. Any theory of disorder in psychiatry will inevitably have to draw boundaries and live with the fact that those are fuzzy. Given the historical background of psychiatry, it is und...

    • Henrik Walter
    • henrik.walter@charite.de
  6. Dec 6, 2017 · We identify four key issues that present challenges to understanding and classifying mental disorder: etiology, including the multiple causality of mental disorder; whether the relevant phenomena are discrete categories or dimensions; thresholds, which set the boundaries between disorder and nondisorder; and comorbidity, the fact that ...

  7. Jan 27, 2020 · Culture in the ICD-11. International classification has the challenge of deciding on appropriate ways of reflecting the influence of culture on the pattern and presentation of mental disorders.