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  1. Jul 9, 2024 · Fever of unknown origin (FUO) is body temperature ≥ 38.3 ° C (≥ 101° F) rectally that does not result from transient and self-limited illness, rapidly fatal illness, or disorders with clear-cut localizing symptoms or signs or with abnormalities on common tests such as chest radiograph, urinalysis, or blood cultures.

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  2. Aug 14, 2023 · Fever of unknown origin (FUO) was first described by Dr. Petersdorf and Dr. Beesom in 1961.[1] FUO was defined as a temperature of 101 degrees Fahrenheit (38.3 degrees Centigrade) or higher with a minimum duration of three weeks without an established diagnosis despite at least one week's investigation in the hospital. This definition was later changed to accommodate technological advances ...

    • Ilona Brown, Nancy A. Finnigan
    • 2023/08/14
    • 2021
  3. Fever of unknown origin: an evidence-based review. Am J Med Sci. 2012;344(4):307-316. Hersch EC, Oh RC. Prolonged febrile illness and fever of unknown origin in adults. Am Fam Physician. 2014;90(2 ...

  4. Feb 2, 2022 · In 1961, Petersdorf and Beeson defined fever of unknown origin (FUO) as a temperature of 38.3°C or higher for at least 3 weeks without a diagnosis, despite 1 week of inpatient investigations. 2 ...

  5. Jun 17, 2015 · Prolonged fevers have been diagnostically problematic since antiquity. Among the ancients, typhoid fever and malaria were common causes of prolonged fevers. 1 Few infections are associated with prolonged fevers. 2 Petersdorf and Beeson 3 developed criteria for prolonged fevers, that is, fever of unknown origin, defined as fever ≥38.3°C (101°F) for >3 weeks that remains undiagnosed after a ...

    • Burke A. Cunha, Burke A. Cunha, Olivier Lortholary, Cheston B. Cunha
    • 2015
  6. Nov 28, 2023 · (See "Fever of unknown origin in adults: Etiologies" and "Fever of unknown origin in children: Evaluation".) DEFINITIONS AND CATEGORIES OF FUO From the perspective of a practicing clinician, an overarching definition of FUO is fever persisting longer than typical self-limiting conditions (eg, common viral illnesses) in the absence of an identifiable cause despite a reasonable evaluation by an ...

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  8. Fever of unknown origin (FUO) often is defined as a fever greater than 38.3°C on several occasions during at least 3 weeks with uncertain diagnosis after a number of obligatory tests. In general, infection accounts for approximately one-fourth of cases of FUO, followed by neoplasm and noninfectious inflammatory diseases.

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