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Fever of unknown origin is defined as a clinically documented temperature of 101°F or higher on several occasions, coupled with an unrevealing diagnostic workup. The differential diagnosis is...
- Roth and Basello
Fever of unknown origin (FUO) in adults is defined as a...
- AAFP
Articles Fever of Unknown Origin in Adults. Aïsha David,...
- Hersch and Oh
Zenone T. Fever of unknown origin in adults: evaluation of...
- Roth and Basello
- On This Page
- Signs and Symptoms
- Asymptomatic Infection
- Incubation Period
- Disease Severity and Risk Factors For Severe Disease
- Sars-Cov-2 Variants of Concern
- Acknowledgements
- Bibliography
COVID-19 includes clinical features that present in varying ways with respect to frequency and severity and vary by age, vaccination status and variants of concern. Published reports often over-represent individuals who have more severe symptoms, and these may differ across care settings and between different age groups and vaccine statuses. Sympto...
A person who is asymptomaticis someone who has tested positive for SARS-CoV-2 test and has never developed any symptoms. During the Omicron wave, a large study in South Africa estimated that 31% of cases were asymptomatic (approximately 1 in 3 cases). This study also reported high viral loads in asymptomatic cases. The asymptomatic carriage rate wa...
The pre-Omicron incubation period for COVID-19 had been estimated to range from 2 to 14 days, with a median of 4-7 days from exposure to symptom onset. Omicron has been found to have an incubation period of a median of 2-4 days, and its associated viral loads have been reported to peak in saliva 1-2 days before positive results can be seen in PCR o...
There is a spectrum of COVID-19 disease severity, ranging from asymptomatic, mild, moderate, to severe and critical disease. Severe disease occurs more often in older age and in those with underlying medical conditions, and the risk increases with the number of underlying medical conditions. The conditions identified below are those for which concl...
The SARS-CoV-2 virus has naturally mutated or changed over time. Mutations may increase or decrease transmissibility or virulence, or lead to immune escape or reduced responses to therapeutics compared to non-variant viruses. Compared to the original strain of SARS-CoV-2, we have seen an increased transmissibility with Omicron. Over time, new varia...
Dr. Marianna Ofner, Dr. Marina Salvadori, Yung-En Chung, Dr. Michael Green, Aidan Pucchio, Denise Gravel-Tropper, Dr. Mireille Plamondon and Dr. Ewa Rajda.
Adamson B, Sikka R, Wyllie AL, Premsriut P. Discordant SARS-CoV-2 PCR and rapid antigen test results when infectious: a December 2021 occupational case series. (2022). medRxiv 22268770 [Preprint]. 2022 Jan 5. Ahmada F., Ahmeda., A, Rajendraprasada S.S., Lorangera F., Guptaa S., Velagapudia M…Moore D. (2021). Multisystem inflammatory syndrome in adu...
Aug 14, 2023 · Etiology. The causes of fever of unknown origin (FUO) are often common conditions presenting atypically. The list of causes is extensive, and it is broken down into broader categories, such as infection, noninfectious inflammatory conditions, malignancies, and miscellaneous.
- Ilona Brown, Nancy A. Finnigan
- 2023/08/14
- 2021
Jun 25, 2024 · Fever of unknown origin (FUO) occurs across all age groups. However, age, together with epidemiological considerations, are important factors in forming a differential diagnosis. In 1961, the first formal criteria for FUO were published, based on a prospective trial. [1]
Jan 27, 2022 · What are symptoms of COVID-19? The most common symptoms are: Cough. Fever or chills. Shortness of breath or difficulty breathing. Muscle or body aches. Sore throat. New loss of taste or smell. Diarrhea. Headache. Fatigue. Nausea or vomiting. Congestion or runny nose.
FEVER OF unknown origin (FUO) identifies a syndrome of fever that does not resolve spontaneously, in which the cause remains elusive after an extensive diagnostic workup.
Nov 28, 2023 · From the perspective of a practicing clinician, an overarching definition of FUO is fever persisting longer than typical self-limiting conditions (eg, common viral illnesses) in the absence of an identifiable cause despite a reasonable evaluation by an experienced clinician.
