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  1. Nov 28, 2023 · From the perspective of a practicing clinician, an overarching definition of FUO is fever persisting longer than typical self-limiting conditions (eg, common viral illnesses) in the absence of an identifiable cause despite a reasonable evaluation by an experienced clinician.

  2. Nov 20, 2023 · This topic discusses etiologies of classic fever or unknown origin. Other categories of FUO, not discussed in this topic, include health care-associated FUO, FUO in immunocompromised patients, and travel-associated FUO.

  3. Clinicians commonly refer to a febrile illness without an initially obvious etiology (sometimes called fever without localizing signs) as fever of unknown origin (FUO). This usage is not accurate. Most febrile illnesses either resolve before a diagnosis can be made or develop distinguishing characteristics that lead to a diagnosis.

  4. Aug 14, 2023 · Fever of unknown origin (FUO) was first described by Dr. Petersdorf and Dr. Beesom in 1961. FUO was defined as a temperature of 101 degrees Fahrenheit (38.3 degrees Centigrade) or higher with a minimum duration of three weeks without an established diagnosis despite at least one week's investigation in the hospital.

    • Ilona Brown, Nancy A. Finnigan
    • 2023/08/14
    • 2021
  5. Feb 2, 2022 · In 1961, Petersdorf and Beeson defined fever of unknown origin (FUO) as a temperature of 38.3°C or higher for at least 3 weeks without a diagnosis, despite 1 week of inpatient investigations....

  6. Feb 1, 2022 · Fever of unknown origin is defined as a clinically documented temperature of 101°F or higher on several occasions, coupled with an unrevealing diagnostic workup. The differential diagnosis is broad but is typically categorized as infection, malignancy, noninfectious inflammatory disease, or miscella ….

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  8. sso.uptodate.com › contents › fever-of-unknownUpToDate

    The approach to the child with FUO, FWS, and fever in unique host groups (eg, newborns, neutropenic children) are discussed separately. (See "Fever of unknown origin in children: Evaluation".) (See "Fever without a source in children 3 to 36 months of age: Evaluation and management".)

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