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  1. Nov 28, 2023 · From the perspective of a practicing clinician, an overarching definition of FUO is fever persisting longer than typical self-limiting conditions (eg, common viral illnesses) in the absence of an identifiable cause despite a reasonable evaluation by an experienced clinician. Many clinical researchers have attempted to more precisely define FUO ...

  2. Nov 20, 2023 · FUO refers to a prolonged febrile illness without an established etiology despite intensive evaluation and diagnostic testing. The most common causes of FUO in adults will be reviewed here. The evaluation and management of the adult with FUO, and the etiology of FUO in children, are discussed separately. (See "Fever of unknown origin in adults ...

  3. Clinicians commonly refer to a febrile illness without an initially obvious etiology or without localizing signs as fever of unknown origin (FUO). This usage is

  4. Aug 14, 2023 · Fever of unknown origin (FUO) was first described by Dr. Petersdorf and Dr. Beesom in 1961.[1] FUO was defined as a temperature of 101 degrees Fahrenheit (38.3 degrees Centigrade) or higher with a minimum duration of three weeks without an established diagnosis despite at least one week's investigation in the hospital. This definition was later changed to accommodate technological advances ...

    • Ilona Brown, Nancy A. Finnigan
    • 2023/08/14
    • 2021
  5. Jul 9, 2024 · Key Points. Fever of unknown origin (FUO) is body temperature ≥ 38.3° C (≥ 101° F) rectally that does not result from transient and self-limited illness, rapidly fatal illness, or disorders with clear-cut localizing symptoms or signs or with abnormalities on common tests such as chest radiograph, urinalysis, or blood cultures.

    • Larry M. Bush
  6. Feb 2, 2022 · In 1961, Petersdorf and Beeson defined fever of unknown origin (FUO) as a temperature of 38.3°C or higher for at least 3 weeks without a diagnosis, despite 1 week of inpatient investigations. 2 ...

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  8. Feb 1, 2022 · Fever of unknown origin is defined as a clinically documented temperature of 101°F or higher on several occasions, coupled with an unrevealing diagnostic workup. The differential diagnosis is broad but is typically categorized as infection, malignancy, noninfectious inflammatory disease, or miscellaneous. Most cases in adults occur because of ...

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