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  1. Jan 6, 2022 · An elevated ALP is very sensitive in its ability to assess for hepatobiliary disease (i.e. diseases affecting the liver, gallbladder, or bile ducts) in dogs and cats. This means that most dogs with significant liver disease will have an elevated ALP.

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  2. Before we dive into the details of managing high ALP levels in dogs, it’s essential to grasp what ALP is and its role in a dog’s body. Alkaline phosphatase (ALP) is an enzyme produced by various organs in a dog’s body, including the liver, bones, intestines, and kidneys. It plays a crucial role in many metabolic processes, such as ...

  3. Oct 11, 2023 · High ALP levels themselves may not exhibit specific symptoms, but the underlying conditions causing the elevation can lead to signs such as lethargy, loss of appetite, vomiting, diarrhea, jaundice, and changes in urine color. If you notice these symptoms in your dog, it’s essential to consult a veterinarian.

  4. Nov 30, 2023 · High liver enzymes in dogs can have a multitude of causes, and the outlook may vary significantly. To help you sort through your dog’s liver enzyme elevations, integrative veterinarian Dr. Julie Buzby explains the four main liver enzymes (ALT, AST, ALP, and GGT) and discusses the causes, diagnosis, treatment, and prognosis for high liver ...

  5. Nov 1, 2010 · An increase in serum alkaline phosphatase (ALP) activity is a common laboratory finding in dogs. It is typically used as a diagnostic marker for cholestatic liver disease. However, increased ALP activity has a high sensitivity (86%) but poor specificity (49%) for canine liver disease.

  6. Feb 5, 2023 · ALT should be tucked inside of the liver cell. When it comes out into the blood at higher than normal levels, this indicates that something is irritating the liver cell membrane, allowing the enzyme to leak out of the cell. Vets become concerned when this enzyme gets too high because it means that something is irritating or damaging the liver.

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  8. Jul 18, 2016 · ALP is a heterogeneous group of enzymes with poorly defined biologic functions that catalyze the hydrolysis of phosphate from various organic compounds at an alkaline pH. Normally bound to cellular membranes, ALP has been isolated from the kidney, liver, bone, placenta, and intestine. Two genes encode for ALP: tissue nonspecific (TNS) and ...

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