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In genetics, a promoter is a sequence of DNA to which proteins bind to initiate transcription of a single RNA transcript from the DNA downstream of the promoter. The RNA transcript may encode a protein (mRNA), or can have a function in and of itself, such as tRNA or rRNA.
Oct 31, 2023 · promoter: the section of DNA that controls the initiation of RNA transcription. This page titled 16.6: Eukaryotic Gene Regulation - The Promoter and the Transcription Machinery is shared under a CC BY-SA 4.0 license and was authored, remixed, and/or curated by Boundless. When transcription factors bind to the promoter region, RNA polymerase is ...
- CORE Promoter
- Proximal Promoter
- Distal Promoter
The core promoter region is located most proximal to the start codon and contains the RNA polymerase binding site, TATA box, and transcription start site (TSS). RNA polymerase will bind to this core promoter region stably and transcription of the template strand can initiate. The TATA box is a DNA sequence (5'-TATAAA-3') within the core promoter re...
Further upstream from the core promoter you will find the proximal promoter which contains many primary regulatory elements. The proximal promoter is found approximately 250 base pairs upstream from the TSS and it is the site where general transcription factors bind.
The final portion of the promoter region is called the distal promoter which is upstream of the proximal promoter. The distal promoter also contains transcription factor binding sites, but mostly contains regulatory elements.
The ultimate "expression" of a gene is its effect on phenotype. If the gene encodes a protein, one might reasonably propose that "expression" of a gene means how much functional protein is made, and that measuring the amount of that protein might be a good measure of "gene expression". Many molecular biologists refer to the level of that gene's ...
promoter. Promoter sequences are DNA sequences that define where transcription of a gene by RNA polymerase begins. Promoter sequences are typically located directly upstream or at the 5' end of ...
Jun 26, 2018 · The important role of the core-promoter sequence in conferring these functions was recently corroborated by analysing single nucleotide polymorphisms and other genetic variants, which across ...
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2 days ago · Definition. A promoter, as related to genomics, is a region of DNA upstream of a gene where relevant proteins (such as RNA polymerase and transcription factors) bind to initiate transcription of that gene. The resulting transcription produces an RNA molecule (such as mRNA).
