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May 16, 2023 · Targeted therapies are a class of agents that inhibit specific cell proteins involved in cancer. A variety of these agents, some approved as standard therapy, some being tested in clinical trials, take aim at proteins that play a key role in the cell cycle.
Sep 10, 2021 · This Review discusses our current understanding of cell cycle regulation, the functions of cell cycle checkpoints and how disruption of these finely tuned mechanisms is associated with cancer.
- Helen K Matthews, Helen K Matthews, Cosetta Bertoli, Robertus A M de Bruin
- 2021
Jan 1, 2021 · Cell-Cycle Targets for Cancer Therapy. One of the hallmarks of cancer cells is the deregulation of cell-cycle controls. Because of their importance in regulating cell proliferation, one would expect that several cell-cycle regulators would have emerged as effective anticancer targets.
Aug 14, 2023 · Cyclins and Cyclin-dependent kinases, also known as CDK's, are the 2 major proteins that play a role in regulating the cell cycle. These CDK's are created throughout the cell cycle and are used to phosphorylate downstream proteins essential for healthy cell growth.
- Anthony A. Mercadante, Anup Kasi
- University of Yale, University of Kansas
- 2021
- 2023/08/14
Nov 1, 2023 · To combat the dysregulation of the cell cycle in cancer, various therapeutic strategies have been developed, including CDK inhibitors, cyclin inhibitors, and checkpoint activators. These treatments can halt the progression of the cell cycle, promote DNA repair, and induce cell death in cancer cells.
Nov 1, 2017 · In this review, we discuss the mechanisms underlying cell cycle regulation and present small-molecule anticancer drugs that are under development, including both pan-CDK inhibitors and CDK4/6-selective inhibitors.
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Jul 22, 2021 · Aberrancy in cell cycle progression is one of the fundamental mechanisms underlying tumorigenesis, making regulators of the cell cycle machinery rational anticancer therapeutic targets.
