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Acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs)
- Acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) are first-line treatment options for most patients with acute mild to moderate pain. Topical NSAIDs are recommended for non–low back, musculoskeletal injuries.
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Acute pain is a complex process involving activation of nociceptors, chemical mediators and inflammation. Medications can be used to target each of the key elements within the pain pathway and eliminate or reduce the sensation of pain.
Oct 9, 2017 · What I do need are doctors willing to listen, empathize, and work with me to identify the most appropriate treatment plan that will minimize my pain and address the underlying condition as best as possible.
- hhp_info@health.harvard.edu
Acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) are first-line treatment options for most patients with acute mild to moderate pain. Topical NSAIDs are recommended for...
This systematic review will assess the comparative effectiveness of treatments and harms of opioid and nonopioid treatments for surgical and nonsurgical pain related to eight acute pain conditions (back pain, neck pain, other musculoskeletal pain, neuropathic pain, postoperative pain [excluding inpatient management of pain following major ...
- 2020/12
- I. Background and Objectives For The Systematic Review
- II. The Key Questions
- III. Methods
- IV. References
- VI. Technical Experts
- VII. Peer Reviewers
- VIII. EPC Team Disclosures
- IX. Role of The Funder
- X. Registration
- Appendix 1. Medline Search Strategies
Pain is nearly universal, contributing substantially to morbidity, mortality, disability, and health care system burdens.1,2 Acute pain has been defined as "the physiologic response and experience to noxious stimuli that can become pathologic, is normally sudden in onset, time limited, and motivates behaviors to avoid actual or potential tissue inj...
Each Key Question (KQ) for this review focuses on a specific acute pain condition. The conditions and related subquestions are listed below: KQ1:Acute back pain (including back pain with radiculopathy) KQ2:Acute neck pain (including neck pain with radiculopathy) KQ3:Musculoskeletal pain not otherwise included in KQ1 or KQ2 (including fractures) KQ4...
Criteria for Inclusion/Exclusion of Studies in the Review
The criteria for inclusion and exclusion of studies will be based on the Key Questions and are described in the previous PICOTS section. Key Questions on opioid and nonopioid therapy focus on comparative effectiveness because the effectiveness of analgesics for treating acute pain are well established. Key Questions on nonopioid therapies include comparisons against sham, waitlist, usual care, attention control, and no therapy due to greater uncertainty regarding their role in management of a...
Searching for the Evidence: Literature Search Strategies for Identification of Relevant Studies to Answer the Key Questions
Publication Date Range:Electronic searches for evidence were conducted in August 2019, and were conducted back to the inception of each database. Electronic searches will be updated while the draft report is out for public review to identify new publications. Literature identified during the updated search will be assessed by following the same process of dual review as all other studies considered for inclusion in the report. If any pertinent new literature is identified for inclusion in the...
Data Abstraction and Data Management
After studies are selected for inclusion, data will be abstracted into categories that include but are not limited to: study design, year, setting, country, sample size, eligibility criteria, population and clinical characteristics, intervention characteristics, and results relevant to each Key Question as outlined in the previous PICOTS section. Information that will be abstracted that is relevant for assessing applicability will include the number of patients randomized relative to the numb...
Institute of Medicine. Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research. Washington, D.C.: The National Academies Press; 2011.Henschke N, Kamper SJ, Maher CG. The epidemiology and economic consequences of pain. Mayo Clin Proc. 2015 Jan;90(1):139-47. doi: 10.1016/j.mayocp.2014.09.010. PMID: 25572198.Tighe P, Buckenmaier CC, 3rd, Boezaart AP, et al. Acute pain medicine in the United States: a status report. Pain Med. 2015 Sep;16(9):1806-26. doi: 10.1111/pme.12760. PMID: 26535424.Kent ML, Tighe PJ, Belfer I, et al. The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) multidimensional approach to classifying acute pain conditions. Pain Med. 2017 May 1;18(5):947-58. doi: 10.1093/pm/pnx...Technical Experts constitute a multi-disciplinary group of clinical, content, and methodological experts who provide input in defining populations, interventions, comparisons, or outcomes and identify particular studies or databases to search. They are selected to provide broad expertise and perspectives specific to the topic under development. Div...
Peer reviewers are invited to provide written comments on the draft report based on their clinical, content, or methodological expertise. The EPC considers all peer review comments on the draft report in preparation of the final report. Peer reviewers do not participate in writing or editing of the final report or other products. The final report d...
EPC core team members must disclose any financial conflicts of interest greater than $1,000 and any other relevant business or professional conflicts of interest. Related financial conflicts of interest that cumulatively total greater than $1,000 will usually disqualify EPC core team investigators.
This project was funded under Contract No. HHSA290201500009I from the Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services. The AHRQ Task Order Officer reviewed contract deliverables for adherence to contract requirements and quality. The authors of this report are responsible for its content. Statements in the r...
This protocol will be registered in the international prospective register of systematic reviews (PROSPERO).
Treatment effectiveness and harms
1. Pain/ 2. Acute Pain/ 3. Pain Management/ 4. (acute adj3 pain).ti,ab,kf. 5. exp back pain/ or exp musculoskeletal pain/ or neck pain/ or exp neuralgia/ or exp Facial Pain/ or exp Nephrolithiasis/ or exp Anemia, Sickle Cell/ or Pain, Postoperative/ 6. (back or spine or spinal or radicular or neck or musculoskeletal or fracture* or neuropathic or neuralgia or neuropathy or sciatica or "dental pain" or "ondotogenic pain" or "kidney stone*" or urolithiasis or nephrolithiasis or "sickle cell" or...
Risk prediction and mitigation
1. Pain/ 2. Acute Pain/ 3. Pain Management/ 4. (acute adj3 pain).ti,ab,kf. 5. exp back pain/ or exp musculoskeletal pain/ or neck pain/ or exp neuralgia/ or exp Facial Pain/ or exp Nephrolithiasis/ or exp Anemia, Sickle Cell/ or Pain, Postoperative/ 6. (back or spine or spinal or radicular or neck or musculoskeletal or fracture* or neuropathic or neuralgia or neuropathy or sciatica or "dental pain" or "ondotogenic pain" or "kidney stone*" or urolithiasis or nephrolithiasis or "sickle cell" or...
Aug 21, 2024 · The goals of acute pain management are to relieve suffering, facilitate function, enhance recovery, and satisfy patients. After surgery, additional goals are to achieve early postoperative mobilization and reduce length of hospital stay.
Mar 31, 2023 · The following outlines the treatment options for acute and chronic pain. Acute. The treatment for acute pain depends on the underlying cause. Initial treatment of acute pain can include:
