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  1. Fever of unknown origin (FUO) was originally defined by Petersdorf and Beeson as an illness of more than 3 weeks’ duration, with fever greater than 38.3 °C (101 °F) on several occasions, the cause of which is uncertain after 1 week of in-hospital investigations.

  2. Fever of unknown origin (FUO) is a serious challenge for physicians. The aim of the present study was to consider epidemiology and dynamics of FUO in countries with different economic development.

  3. Aug 14, 2023 · Epidemiology of fever of unknown origin (FUO) varies based on etiology of fever, age group, geography, environmental exposure, and immune/HIV status. In developing countries, an infectious etiology of FUO is most prevalent whereas, in developed countries, FUO is likely due to non-infectious inflammatory disease.

    • Ilona Brown, Nancy A. Finnigan
    • 2023/08/14
    • 2021
  4. Feb 2, 2022 · In 1961, Petersdorf and Beeson defined fever of unknown origin (FUO) as a temperature of 38.3°C or higher for at least 3 weeks without a diagnosis, despite 1 week of inpatient...

  5. May 2, 2020 · Evolution of the incidence and aetiology of fever of unknown origin (FUO), and survival in HIV-infected patients after HAART (highly active antiretroviral therapy).

    • William F Wright, Paul G Auwaerter
    • 2020
  6. May 2, 2020 · While FUO subgroups and etiologic classifications have remained unchanged since 1991 revisions, the spectrum of diseases, clinical approach to diagnosis, and management are changing. This review considers how newer data should influence both definitions and lingering dogmatic principles.

  7. Jun 10, 2024 · Classic fever of unknown origin (FUO) was first robustly studied in 1961, with subsequent modifications in definitions (Table 1) [1, 2]. These FUO definitions require an illness of ≥3 weeks duration and temperatures of ≥38.3°C (≥100.9°F) on several occasions [1, 2].

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