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Abstract. Body weight in humans is regulated by highly complex interacting neuronal and endocrine pathways that serve to stimulate food intake and reduce e
Nov 13, 2023 · Weight regulation disorders manifest as extreme chronic weight changes with concomitant metabolic derangements. On one extreme is obesity, a condition marked by chronic caloric excess and weight gain. On the other is malnutrition, characterized by severe weight loss or poor weight gain from a chronically negative energy balance.
- Rasik M. Parmar, Ahmet S. Can
- 2023/11/13
- [35]
Jun 13, 2024 · Body weight reflects the chronic balance between energy intake and energy expenditure. The pathophysiology of weight loss and gain is complex with genetic, physiological, and environmental factors contributing to a person’s ability to maintain, lose or gain weight. The inability for the body to counteract chronic caloric surplus leads to overweight and obesity. Among U.S. adults, overweight ...
- Nicholas T Broskey, Darcy Johannsen, Leanne Redman
- 2024/06/13
- 2016
disorders have focused on genes involved in body weight regulation and feeding, such as leptin, the melanocortin MC receptor, and estrogen receptor genes, as implicated in animal feeding models. Most of such investigations, which assess for higher than expected transmission of particular polymorphisms in persons with AN or BN, have yielded
- 266KB
- 16
Apr 25, 2020 · The Physiology of Weight Regulation. As mentioned above , the adipokine leptin acts as a signal of long-term energy availability (fat mass), promoting satiety via its inhibitory action on orexigenic neurons located in the ARC of the hypothalamus . A recent report of a patient with leptin deficiency highlights key interactions between leptin and ...
- Andrea Pucci, Rachel L Batterham
- 2020/04/25
- 2020
Abstract. Obesity is a chronic, multifactorial, and morbid disease. In the United States, 69% of adults are overweight or have obesity, and the global prevalence of obesity is increasing. Obesity is influenced by genetic, neurologic, metabolic, enteric, and behavioral processes. It remains a key modi fiable risk factor for many comorbid ...
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In a weight maintenance trial, obese patients who lost an average 6.0% with a low-calorie diet, lost an additional 6.2% weight with liraglutide (vs. 0.2% for placebo) over a year (94). A CVOT with a median follow-up of 3.8 years demonstrated lower MACE incidence with liraglutide 1.8 mg among patients with T2D (95).
