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Pathogenesis
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- Pathogenesis—or “origin of disease”—is the study of the processes that give rise to physiologic dysfunction and illness.
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What is a 'web of causation' in epidemiology?
What is the 'web' in epidemiology?
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What is an example of a Good Epidemiology and a web of causation?
Apr 4, 2016 · The web of causation argues that there are many factors that may result in a disease occurring. Each of these on its own may contribute to someone actually becoming ill from the disease.
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- Overview
- Major distinctions
- Noncommunicable disease
disease, any harmful deviation from the normal structural or functional state of an organism, generally associated with certain signs and symptoms and differing in nature from physical injury. A diseased organism commonly exhibits signs or symptoms indicative of its abnormal state. Thus, the normal condition of an organism must be understood in order to recognize the hallmarks of disease. Nevertheless, a sharp demarcation between disease and health is not always apparent.
The study of disease is called pathology. It involves the determination of the cause (etiology) of the disease, the understanding of the mechanisms of its development (pathogenesis), the structural changes associated with the disease process (morphological changes), and the functional consequences of those changes. Correctly identifying the cause of a disease is necessary to identifying the proper course of treatment.
The normal state of an organism represents a condition of delicate physiological balance, or homeostasis, in terms of chemical, physical, and functional processes, maintained by a complex of mechanisms that are not fully understood. In a fundamental sense, therefore, disease represents the consequences of a breakdown of the homeostatic control mechanisms. In some instances the affected mechanisms are clearly indicated, but in most cases a complex of mechanisms is disturbed, initially or sequentially, and precise definition of the pathogenesis of the ensuing disease is elusive. Death in humans and other mammals, for example, often results directly from heart or lung failure, but the preceding sequence of events may be highly complex, involving disturbances of other organ systems and derangement of other control mechanisms.
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The initial cause of the diseased state may lie within the individual organism itself, and the disease is then said to be idiopathic, innate, primary, or “essential.” It may result from a course of medical treatment, either as an unavoidable side effect or because the treatment itself was ill-advised; in either case the disease is classed as iatrogenic. Finally, the disease may be caused by some agent external to the organism, such as a chemical that is a toxic agent. In this case the disease is noncommunicable; that is, it affects only the individual organism exposed to it. The external agent may be itself a living organism capable of multiplying within the host and subsequently infecting other organisms; in this case the disease is said to be communicable.
Noncommunicable diseases generally are long-lasting and progress slowly, and thus they are sometimes also referred to as chronic diseases. They can arise from environmental exposures or from genetically determined abnormalities, which may be evident at birth or which may become apparent later in life. The World Health Organization (WHO) has identified four major types of noncommunicable disease: cancer, cardiovascular disease (e.g., heart attack, stroke), chronic respiratory disease (e.g., asthma), and diabetes mellitus. WHO estimates that, combined, these four groups of conditions account for 82 percent of all deaths from noncommunicable disease.
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Noncommunicable diseases that arise from inherited genetic abnormalities often leave an individual ill-equipped to survive without some form of treatment. Examples of inherited disease include cystic fibrosis, Down syndrome, and inborn errors of metabolism, which are present at birth. Examples of inherited diseases that emerge in adulthood include Huntington disease and certain forms of cancer (e.g., familial breast cancer involving inherited mutations in either of the genes BRCA1 or BRCA2).
Jan 12, 2016 · The web of causation offers a useful way forward in understanding aetiology and linking social determinants and social factors and biomedical aetiological factors. The web of causation emphasises proximate determinants of disease amenable to intervention through individual level health care but taking into account larger social networks (see ...
- Antonio Ventriglio, Antonello Bellomo, Dinesh Bhugra
- 2016
Oct 1, 1994 · First articulated in a 1960 U.S. epidemiology textbook, the `web' remains a widely accepted but poorly elaborated model, reflecting in part the contemporary stress on epidemiologic methods over epidemiologic theories of disease causation.
- Nancy Krieger
- 1994
'Multiple causation' is the canon of contemporary epidemiology, and its metaphor and model is the 'web of causation.' First articulated in a 1960 U.S. epidemiology textbook, the 'web' remains a widely accepted but poorly elaborated model, reflecting in part the contemporary stress on epidemiologic m …
- Nancy Krieger
- 1994
The aim of this article is to introduce readers to the key tenets of critical realism, explore how it can offer healthcare providers and researchers deeper levels of explanation and understanding of causation, and examine some potential limitations of this approach.
Koch and Pasteur provided modern medicine with its primary model of disease – that it has a specific and organic cause. Treatment is generally developed from an understanding of that agent of causation. Generations of medical students have been taught the causes of disease in their pathology classes: genetic, infection, trauma and so on.
