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  1. U.S. Route 50 (US 50) runs east–west across the southern part of the state of Ohio, passing through Cincinnati, Chillicothe, and Athens. It is mainly a two-lane road except for the easternmost and westernmost parts.

  2. Nov 4, 2022 · U.S. Route 50 is a 3,200-mile road that spans 11 states and showcases some of America’s most beautiful scenery -- especially in Ohio. This route winds its way through the entire southern portion of Ohio, showing off some of the Buckeye State's best rural scenery and most charming small towns.

  3. US‑50: Across Cincinnati. US-50 survives pretty much intact across Cincinnati, though most of its former traffic now follows the freeways that loop around and cut through the city. West of downtown, US-50 follows the Ohio River along River Road, but the old alignment veers away from the freeway-sliced waterfront along State Avenue, running ...

  4. Travel US 50 through Ohio, OH. The Buckeye State. The Heart of It All! Columbus is the Capital. State motto is: With God, all things are possible.

  5. Aug 4, 2021 · Near Cincinnati, a small stretch of the route runs along The Ohio River Scenic Byway, which is a gorgeous route that features great views of the river. You'll likely notice several historic markers as you pass through small towns and villages, as Route 50 follows the footsteps of pioneers.

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  7. Highway 50 winds from the cities of Washington, D.C., Cincinnati, St. Louis, Kansas City, and Sacramento, to the remote mountains of the West Virginia Appalachians and Colorado’s Rockies, to the vast farming country of the Midwest and Ohio River Valley, and ultimately through the now-legendary loneliness of Nevada and Utah’s Great Basin Desert.

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