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In this review, we aim to provide a comprehensive view of the complex role that platelets play in hemostasis and thrombosis, and to discuss the major clinical implications of these fundamental blood components, with a focus on hemostatic platelet-related disorders and existing and emerging antithrombotic therapies.
- Mechanism Action of Platelets and Crucial Blood Coagulation ...
However, platelets are the smallest blood component produced...
- Platelets in hemostasis and thrombosis: Novel mechanisms of ...
Furthermore, whilst platelets play a pivotal role in...
- Physiology, Platelet - StatPearls - NCBI Bookshelf
Platelets are small blood cells with several physiological...
- Mechanism Action of Platelets and Crucial Blood Coagulation ...
However, platelets are the smallest blood component produced from the very large bone marrow cells called megakaryocytes and they play a fundamental role in thrombosis and hemostasis. Platelets contribute their hemostatic capacity via adhesion, activation and aggregation, which are triggered upon tissue injury, and these actions stimulate the coagulation factors and other mediators to achieve ...
Furthermore, whilst platelets play a pivotal role in hemostasis and thrombosis, they are also versatile cells and are involved in multiple functions, including inflammation, immune responses, lymphatic vessel development, angiogenesis, tumor metastasis, as well as atherosclerosis [106-109]. Further elucidations of platelet versatilities will provide insights into development of new methods to ...
Oct 23, 2022 · platelets play in hemostasis and thrombosis, and to discuss the major clinical implications of these fundamental blood components, with a focus on hemostatic platelet-related disorders and ...
- Alina Scridon
Oct 23, 2022 · Hemostasis is a physiological process critical for survival. Meanwhile, thrombosis is amongst the leading causes of death worldwide, making antithrombotic therapy one of the most crucial aspects of modern medicine. Although antithrombotic therapy has progressed tremendously over the years, it remains far from ideal, and this is mainly due to the incomplete understanding of the exceptionally ...
Jul 25, 2023 · Platelets are small blood cells with several physiological purposes; the best studied is thrombosis activation. Through their clotting activity and activation of the coagulation cascade, they are crucial to maintaining adequate blood volume in those with vascular injury. The initiation of this activity begins with tissue injury and results in the release and binding of several glycoproteins ...
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Dec 10, 2011 · The primary hemostatic function of platelets has been recognized for more than a century, and the molecular processes regulating the adhesive function of platelets have been elucidated in great detail. 2–4 In addition to preventing excess bleeding, platelets also play an important role in surveying and maintaining the integrity of the endothelium, in part through the release of proangiogenic ...
