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Abstract. Osteoclasts are multinucleated bone-resorbing cells and a key player in bone remodeling for health and disease. Since the discovery of osteoclasts in 1873, the structure and function of osteoclasts and the molecular and cellular mechanisms of osteoclastogenesis have been extensively studied. Moreover, it has been well established that ...
Osteoclasts come from a different cell source, originating from mononuclear cells of the hematopoietic lineage (Crockett et al., 2011; Asagiri and Takayanagi, 2007), which upon differentiation and activation form large, multinucleated, highly motile cells that carry out their bone resorption activity. Actively resorbing osteoclasts polarize and their plasma membrane assumes a folded appearance ...
Aug 17, 2020 · Osteoclasts are the only bone-resorbing cells and are differentiated from myeloid lineage precursor cells 1,2,3,4,5.Osteoclasts play important roles in both homeostatic bone remodeling and ...
- Se Hwan Mun, Peter Sang Uk Park, Kyung-Hyun Park-Min, Kyung-Hyun Park-Min
- 2020
Osteoclasts are multinucleated cells created by the fusion of osteoclast progenitor cells (OCPs) with the capacity to dissolve bone matrix via secreting H+, Cl−, cathepsin K (CTSK), and matrix metalloproteinases (MMPs) in the resorption zone in response to macrophage colony stimulating factor (M-CSF) and receptor activator of NFkB ligand (RANKL).In addition, the differentiation and activity ...
Apr 24, 2023 · Functioning as vital cells in the bone matrix that maintains adequate bone mineral density through stimulating bone turnover and maintaining plasma calcium levels, osteoclasts are multinucleate cells that arise from hematopoietic stem cells.[1][2][3][4] As a result, they are identifiable with the presence of CD13, CD14, and CD68 antigens and the lack of CD56, GrB, and Ki67 antigens.[5] When ...
- Irfan A. Khan, Bruno Bordoni
- 2023/04/24
Feb 1, 2024 · Osteoclasts are the principal cells that efficiently resorb bone. Numerous studies have attempted to reveal the molecular pathways leading to the differentiation and activation of osteoclasts to ...
Feb 10, 2021 · Osteoclasts derived from hematopoietic precursor cells of the phagocyte lineage and differentiate into giant multinucleated cells by the fusion of osteoclast precursors. 1,103 Mature osteoclasts have highly specialized morphological structures such as actin rings, sealing zone, and ruffled borders that construct an efficient machinery for dissolving hydroxyapatite and degrading bone matrix.
