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      • The route crosses southern Ohio via Hillsboro, Chillicothe, and Athens, joining the four-lane divided Corridor D (State Route 32) west of Athens. It meets the Ohio River around Belpre, and crosses the newer Blennerhassett Island Bridge (previously crossing the Parkersburg-Belpre Bridge) into greater Parkersburg, West Virginia.
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  2. Route map: U.S. Route 50 (US 50) runs eastwest across the southern part of the state of Ohio, passing through Cincinnati, Chillicothe, and Athens. It is mainly a two-lane road except for the easternmost and westernmost parts.

  3. After bisecting Missouri from Kansas City to St. Louis, US-50 crosses the Mississippi River into a much older and more settled landscape, through the agricultural heartlands of Illinois, Indiana, and Ohio.

  4. While traversing through the Midwest, one can visit major cities such as St Louis, and Kansas City in Missouri, and Cincinnati in Ohio, as well as many rural areas. In the eastern United States, US Route 50 continues through the Appalachian Mountains in West Virginia.

  5. Route map: U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80) in West Sacramento, California, to Maryland Route 528 (MD 528) in Ocean City, Maryland, on the Atlantic Ocean.

  6. Jul 29, 2017 · Route 50 in Ohio. Route 50 enters eastern Ohio from Parkersburg, West Virginia, by crossing the Ohio River. After 200 miles of rolling countryside and small towns, it reaches the Ohio River again at Cincinnati, where the river forms the border with Kentucky. It then follows the river west to Indiana.

  7. US 50 is Main Street through town, a quaint small town with many old buildings. Paint Creek runs west of town. Chillicothe was the first and third Capital of Ohio.

  8. In the Midwest, US 50 goes through mostly rural areas of farms, although it does go through a few big cities including Kansas City, Missouri; St. Louis, Missouri; and Cincinnati, Ohio. The route goes into the eastern United States, where it goes through the Appalachian Mountains in West Virginia; then it goes through Washington, D.C.

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