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Route map: U.S. Route 50 (US 50) runs east–west across the southern part of the state of Ohio, passing through Cincinnati, Chillicothe, and Athens. It is mainly a two-lane road except for the easternmost and westernmost parts.
While traversing through the Midwest, one can visit major cities such as St Louis, and Kansas City in Missouri, and Cincinnati in Ohio, as well as many rural areas. In the eastern United States, US Route 50 continues through the Appalachian Mountains in West Virginia.
A road trip along US-50 follows time from colonial-era landscapes through the Wild West to high-tech Silicon Valley, the best route for the unhurried.
Nov 4, 2022 · U.S. Route 50 is a 3,200-mile road that spans 11 states and showcases some of America’s most beautiful scenery -- especially in Ohio. This route winds its way through the entire southern portion of Ohio, showing off some of the Buckeye State's best rural scenery and most charming small towns.
Find local businesses, view maps and get driving directions in Google Maps.
US 50 is Main Street through town, a quaint small town with many old buildings. Paint Creek runs west of town. Chillicothe was the first and third Capital of Ohio.
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U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80) in West Sacramento, California, to Maryland Route 528 (MD 528) in Ocean City, Maryland, on the Atlantic Ocean.
