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- Emmy Rossum as Fiona Gallagher. For nine seasons, Rossum played Fiona, the oldest of the five Gallagher children who hail from Chicago's South Side. The star's fierce, mother-figure character took on every challenge her dysfunctional family threw at her as she worked odd jobs to support her siblings.
- Jeremy Allen White as Lip Gallagher. Lip — fan-favorite and second in charge — was played by White throughout all 11 seasons. Since the show's debut in 2011, the star has also appeared in The Time Being (2012), Bad Turn Worse (2013), The Rental (2020), The Birthday Cake (2021) and several shorts.
- William H. Macy as Frank Gallagher. Macy had a storied career before his role as Frank, an alcoholic absentee father who often serves as the family's constant headache.
- Steve Howey as Kevin Ball. Howey plays Kevin Ball, the good-natured friend of the Gallagher family and bartender at Frank's favorite neighborhood bar. Before landing Shameless, the actor played Van Montgomery on Reba from 2001 to 2007 and appeared on episodes of New Girl, Sons of Anarchy, Workaholics and Law & Order: SUV while filming the show.
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- William H. Macy (Frank Gallagher) While most people try to make their mark in the world, Frank Gallagher leaves a stain. He can hold down his liquor but not a job, and though he's the patriarch of the family, he puts the "issues" in daddy issues.
- Emmy Rossum (Fiona Gallagher) Fiona is like the glue of the Gallaghers: She holds things together and can sometimes get you high. As the eldest sibling with an estranged mother and a selfish deadbeat father, Emmy Rossum's character is tasked with raising the family while also raising hell and battling her own personal demons.
- Jeremy Allen White (Phillip "Lip" Gallagher) The second eldest sibling — and arguably the smartest — Lip is not immune from the Gallagher gene of being self-destructive.
- Joan Cusack (Sheila Jackson) Joan Cusack's Emmy award-winning portrayal of Sheila, the agoraphobic dominatrix with disability checks, almost never came to be.
- David Threlfall - Frank Gallagher. Leading star of the show is David Threlfall who played Frank, the head of the Gallagher family. Frank was known for his drunken rants.
- Annabell Apsion - Monica Gallagher. Annabell Apsion took on the role of Frank's estranged wife Monica in the series. More recently, whoever, she's starred as Beattie May in Father Brown and as Violet Buckle in Call the Midwife.
- Anne-Marie Duff - Fiona McBride. The eldest of the Gallagher children was Fiona – played by BAFTA nominated actress Anne-Marie Duff. Anne-Marie has appeared in plenty of other films and TV shows since appearing in the comedy, but most recently she's known for appearing as Erin Wiley in Netflix's Sex Education and as Tracy Daszkiewicz in the BBC drama The Salisbury Poisonings.
- Jody Latham - Lip Gallagher. Phillip 'Lip' Gallagher is played by Jody Latham. Jody is perhaps best-known for his work in the Channel 4 comedy, but has had roles in other popular TV shows since including Casualty, Holby City and Inspector George Gently.
- William H. Macy (Frank) William H. Macy, who played the Gallaghers' unreliable alcoholic father, most recently appeared in an episode of ABC’s The Conners as Dan’s former high-school classmate, Smitty Cusamano.
- Emma Kenney (Debbie) When Emmy Kenney started playing Debbie, the Gallagher family’s precocious (and adorably crooked) kid entrepreneur, she was just 12 years old.
- Emmy Rossum (Fiona) Emmy Rossum said goodbye to playing Fiona, the Gallagher family's de facto matriarch, at the end of Season 9. She’s since had two children (a son and a daughter, both of whom she gave birth to in secret) with husband Sam Esmail and starred in Peacock’s Angelyne, which tells the true story of a Los Angeles-based woman who engineered her celebrity in the '80s by posing for mysterious billboards.
- Cameron Monaghan (Ian) Cameron Monaghan, one half of Shameless's most beloved ship—Ian and Mickey—has been delighting Star Wars and video-game fans alike by voicing protagonist Cal Kestis in Star Wars Jedi: Fallen Order, which came out in 2019; and Star Wars Jedi: Survivor, which was released in April 2023.
- Emmy Rossum. From bubby brunette to one chic woman! During her eight-year stint on the show, Emmy became a staple on the series and made her directorial debut.
- William H. Macy. Perhaps the most established actor when the show debuted, William hasn’t changed much during the show’s run. Looking back, it’s hard to imagine anyone else playing Frank.
- Jeremy Allen White. Jeremy Allen White, who plays Phillip (a.k.a “Lip”), has really transformed from a being cutesy teen. The actor welcomed a new baby into the world with his longtime girlfriend, Addison Timlin, in October 2018.
- Cameron Monaghan. Cameron Monaghan has been a regular on Shameless since he was just 15. Like his older costar, Cameron also decided to leave his longtime role.
Apr 6, 2023 · The cast of 'Shameless' underwent a lot of changes during the show's 11 seasons — find out what the actors are doing now Gallaghers forever! The long-running dramedy Shameless wrapped up its...
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Mar 13, 2020 · Emmy Rossum (Fiona Gallagher) As Fiona Gallagher, the oldest sibling who took on most of the responsibilities in the multi-child house, Emmy Rossum played her most well-known role to date in...
