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Sep 3, 2021 · Proving useful in research of antifungal drugs and interactions between fungal pathogens and hosts, yeast was also used as a model for studying prion related diseases, Alzheimer’s disease and cancer, amongst others.
- Dusan Pesic
- 2021
Dec 29, 2015 · Budding yeast, S. cerevisiae, has been used extensively as a model organism for studying cellular processes in evolutionarily distant species, including humans. However, different human tissues, while inheriting a similar genetic code, exhibit distinct anatomical and physiological properties.
Probably the best examples of the value of yeast as a model system concern human disease genes that have been mapped by linkage, positionally cloned, and then sequenced. Usually nothing is known of these genes beyond the fact that their inheritance results in disease.
In this review, we discuss the characteristics that made yeast such an extensively used model organism and specifically focus on the DNA damage response pathway as a prime example of how research in S. cerevisiae helped elucidate a highly conserved biological process.
- *Corresponding Author: dusan.pesic@mail.mcgill.ca
- Discussion
- Conclusions
- List of Abbreviations Used
- Conflicts of Interest
- Ethics Approval and/or Participant Consent
- Authors' Contributions
- Acknowledgements
Abstract Introduction: The use of yeasts in various fields dates back to thousands of years ago, but their biological significance has only recently been discovered. Genomes of many members of this relatively small group have been sequenced, and the consequent studies on them and on various cell processes have revealed similarities between yeast sp...
While there are other organisms that also have genetic homologies with humans similar to the baker’s yeast, there are impediments in using them for research purposes. If two potential model organisms exhibit the same trait, the simpler one will be chosen. For example, 99% of M. musculus genes have their homologs in humans, higher than any other org...
Morphological, physiological, and genetic characteristics of yeasts, namely S. cerevisiae and Schiz. pombe, give researchers a variety of biological tools they can use: the cultivation environment can be tweaked to modify the yeast metabolism in a certain way, and by knowing its genome sequence and having different databases, it is possible to use ...
S. cerevisiae: Saccharomyces cerevisiae Schiz. pombe: Schizosaccharomyces pombe Schiz. japonicus: Schizosaccharomyces japonicus Schiz. cryophilus: Schizosaccharomyces cryophilus Schiz. octosporus: Schizosaccharomyces octosporus C. elegans: Caenorhabditis elegans D. melanogaster: Drosophila melanogaster SGD: Saccharomyces Genome Database M. musc...
The author declares that he has no conflict of interests.
The study required no ethics approval or participant consent.
DP: contributed to the design of the study, the review of literature and collection of data, interpretation and analysis of the data, and revised the manuscript.
I wish to thank my mentor, Mythili Ravishankar, for her support, help in literature search, and for reviewing the manuscript. I would also like to thank Bi-ru Amy Yeung for carefully reviewing my manuscript several times and helping me with its revision.
Humanized yeast permits the discovery of new human biology by measuring human protein activity in a simplified organismal context. This Review summarizes recent developments showing how humanized yeast can directly assay human gene function and explore variant effects at scale.
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Yeast is a single-celled organism that’s commonly used in genetics research because it has many similarities with our cells. Studying yeast has revealed important information about the biological processes of our cells and led to a deeper understanding of what happens when these processes go wrong.
