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Jan 27, 2023 · He didn’t even think there was such a thing as T cells, because he was an antibody guy, through and through. He just thought it was some kind of weird macrophage that picked up an antibody molecule.” Allison was not convinced. He wanted to understand how these cells worked. “At the time, the T cell receptor hadn’t been discovered.
Feb 6, 2020 · In order to protect the body’s own cells from friendly immune fire, gearing up a T cell to find and destroy its target involved a multistep process, including releasing a critical safety lock ...
Apr 18, 2014 · The Texas T Cell Mechanic. James Allison, PhD, knows his T cells. For the past 30 years, he’s studied them inside and out, learning what makes them run and hum. From his laboratory have emerged some of the most important discoveries in immunology. In the early 1980s, Allison was one of the first to identify the T cell receptor—the part of a ...
Oct 22, 2018 · It made it more fun.” If keying the T-cell receptor with the corresponding antigen wasn’t the only signal needed to turn on a T cell, that meant there had to be another molecule, maybe several ...
The excerpt on Wired magazine of The Breakthrough by Charles Graeber has the following description of how James Allison found the T-cell receptor.. Suddenly it seemed so obvious: If Allision could rig up a way to compare B cells and T cells, devise a lab experiment that put one against the other and let their redundant surface proteins cancel each other out, the receptor should be the molecule ...
Both Allison and Honjo set out to understand how a type of white blood cell called T cells work. T cells can detect invading bacteria, viruses and other dangers such as cancer before multiplying and recruiting other elements of the immune system to join the fight. “They can recognise almost anything that nature throws at you,” Allison explains.
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Why did Allison not think there was a T cell?
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Why was the discovery of T cells so important?
Taking the brake off T cells. The Nobel Prize recognizes Allison’s breakthrough work with T cells, the “soldiers” of the immune system that battle invaders and abnormal cells like cancer, bacteria and viruses. While T cells are fierce opponents of disease, they don’t attack every invader that comes along.
