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Jan 27, 2023 · He didn’t even think there was such a thing as T cells, because he was an antibody guy, through and through. He just thought it was some kind of weird macrophage that picked up an antibody molecule.” Allison was not convinced. He wanted to understand how these cells worked. “At the time, the T cell receptor hadn’t been discovered.
Oct 22, 2018 · Allison’s lab now had a fairly complete picture of the steps required for T-cell activation against disease. First, the T cell needed to recognize the sick cell by its unique protein fingerprint ...
Both Allison and Honjo set out to understand how a type of white blood cell called T cells work. T cells can detect invading bacteria, viruses and other dangers such as cancer before multiplying and recruiting other elements of the immune system to join the fight. “They can recognise almost anything that nature throws at you,” Allison explains.
Oct 1, 2018 · Allison discovered a molecule called CTLA-4, which served as the "brakes" for T cells. So Allison had an idea: "Let's just disable the brakes and see if that will allow the immune system to attack ...
Apr 18, 2014 · The Texas T Cell Mechanic. James Allison, PhD, knows his T cells. For the past 30 years, he’s studied them inside and out, learning what makes them run and hum. From his laboratory have emerged some of the most important discoveries in immunology. In the early 1980s, Allison was one of the first to identify the T cell receptor—the part of a ...
Taking the brake off T cells. The Nobel Prize recognizes Allison’s breakthrough work with T cells, the “soldiers” of the immune system that battle invaders and abnormal cells like cancer, bacteria and viruses. While T cells are fierce opponents of disease, they don’t attack every invader that comes along.
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Why did Allison not think there was a T cell?
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Which molecule affects T cell activity – PD-1 or PD-L1?
Did you know the T cell receptor was not discovered?
How do T cells identify dangers?
Oct 1, 2018 · The surface of T cells now seemed like the best place to look for new molecules that controlled these immune cells. Only a few years later Professor Tasuku Honjo and his team identified another molecule that influences T cell activity, called PD-1. PD-1 sticks to a molecule on cancer cells called PD-L1.
