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Jan 27, 2023 · He didn’t even think there was such a thing as T cells, because he was an antibody guy, through and through. He just thought it was some kind of weird macrophage that picked up an antibody molecule.” Allison was not convinced. He wanted to understand how these cells worked. “At the time, the T cell receptor hadn’t been discovered.
The excerpt on Wired magazine of The Breakthrough by Charles Graeber has the following description of how James Allison found the T-cell receptor.. Suddenly it seemed so obvious: If Allision could rig up a way to compare B cells and T cells, devise a lab experiment that put one against the other and let their redundant surface proteins cancel each other out, the receptor should be the molecule ...
Feb 6, 2020 · The mystery was irresistible for Allison, who surmised that there must be some way the T cells were able to recognize things that weren’t supposed to be there–bacteria, viruses, other ...
Oct 22, 2018 · Allison didn’t believe that T cells were just a cell-killing version of B cells, a sort of killer-B. He believed that if T cells existed (they did) and were different from B cells (they were ...
Apr 18, 2014 · The Texas T Cell Mechanic. James Allison, PhD, knows his T cells. For the past 30 years, he’s studied them inside and out, learning what makes them run and hum. From his laboratory have emerged some of the most important discoveries in immunology. In the early 1980s, Allison was one of the first to identify the T cell receptor—the part of a ...
Apr 18, 2014 · James Allison, Ph.D., knows his T cells. For the past 30 years, he's studied them inside and out, learning what makes them run and hum. From his laboratory have emerged some of the most important discoveries in immunology. In the early 1980s, Allison was one of the first to identify the T cell receptor—the part of a T cell that binds to ...
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Who was Jim Allison?
Allison showed that the protein CTLA-4, which is found on the surface of T cells, acts as a brake — a type of immune system checkpoint the body uses to avoid a dangerously over-reactive immune response. He then developed an antibody to block CTLA-4’s “braking” action, freeing T cells to attack cancer.
