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Jan 27, 2023 · He didn’t even think there was such a thing as T cells, because he was an antibody guy, through and through. He just thought it was some kind of weird macrophage that picked up an antibody molecule.” Allison was not convinced. He wanted to understand how these cells worked. “At the time, the T cell receptor hadn’t been discovered.
Oct 22, 2018 · Allison didn’t believe that T cells were just a cell-killing version of B cells, a sort of killer-B. ... reasons why I think that it is the T-cell antigen receptor,’ and I just listed it out ...
The excerpt on Wired magazine of The Breakthrough by Charles Graeber has the following description of how James Allison found the T-cell receptor.. Suddenly it seemed so obvious: If Allision could rig up a way to compare B cells and T cells, devise a lab experiment that put one against the other and let their redundant surface proteins cancel each other out, the receptor should be the molecule ...
Feb 6, 2020 · The mystery was irresistible for Allison, who surmised that there must be some way the T cells were able to recognize things that weren’t supposed to be there–bacteria, viruses, other ...
Both Allison and Honjo set out to understand how a type of white blood cell called T cells work. T cells can detect invading bacteria, viruses and other dangers such as cancer before multiplying and recruiting other elements of the immune system to join the fight. “They can recognise almost anything that nature throws at you,” Allison explains.
Apr 18, 2014 · The Texas T Cell Mechanic. James Allison, PhD, knows his T cells. For the past 30 years, he’s studied them inside and out, learning what makes them run and hum. From his laboratory have emerged some of the most important discoveries in immunology. In the early 1980s, Allison was one of the first to identify the T cell receptor—the part of a ...
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Who was Jim Allison?
In the late 1960s, James Allison became enthralled by T cells in an undergraduate classroom at the University of Texas at Austin. T cells, newly discovered at time, are immune cells that travel through the body, hunting for invaders or abnormal cells that might cause harm. When they find something suspicious, they multiply and eliminate.
