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Jun 26, 2018 · Cancer cells' relationship with oxygen is a bit more complicated, and that realization has led to decades of research into whether oxygen is good for cancer or bad for it. The answers are still not definitive, but some have used the unknowns to fuel unsupported claims that certain types of oxygen therapies, including hyperbaric oxygen (HBO) therapy, can cure cancer.
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Nov 30, 2022 · Published systematic reviews and meta-analyses of palliative oxygen in cancer patients have limitations as they mostly include short-term trials in non-hypoxemic patients. 10,11 The largest randomized trial of palliative oxygen in relief of dyspnea in patients with refractory dyspnea is a long-term, multicenter double-blinded randomized controlled trial that compared oxygen 2 L per minute vs ...
- Study Design and Population
- Study Variables
- Statistical Analysis
This was a cohort study conducted at a primary care practice in suburban Tokyo. Adult patients aged 20 years or older with locally advanced or metastatic cancer followed by a home medical care service provided by the practice were screened. Patients with first low oxygen saturation (peripheral arterial oxygen saturation measured by pulse oximetry <...
All data on study variables were obtained by retrospective chart review. The exposure was the use of oxygen at home. The decision regarding whether to start supplemental oxygen was made following discussion between the patient, the family and the physician. The patient and family’s wishes were respected. Whether to recommend supplemental oxygen was...
Medians with corresponding interquartile range (IQR) were calculated for overall survival and survival at home using the Kaplan–Meier survival function. The statistical significance of estimates from Kaplan–Meier survival curves for overall survival and survival at home were tested using the log-rank test. The statistical significance of the differ...
- Hiroshi Igarashi, Motoharu Fukushi, Naoki Nago
- 2020
The benefit of supplemental oxygen for relief of breathlessness (palliative oxygen therapy) and for improving physical capacity and activity in daily life has not been established.98–100 While supplemental oxygen is indicated in patients with chronic severe hypoxaemia (partial pressure of oxygen (PaO 2) <7.4 kPa or peripheral oxygen saturation (SpO 2) <89% at rest) to prolong life,101 oxygen ...
Nov 22, 2019 · A key component of the body’s oxygen-sensing system is a set of molecular hypoxia-inducible factors, or HIFs, which can respond to a need for more oxygen by turning on genes and proteins that recruit new networks of blood vessels. Cancer cells in a growing tumor can adapt to oxygen deprivation by hijacking these HIFs.
Studies from this time demonstrated a relationship between tumor oxygenation and response to radiation therapy in both cervical and head and neck cancer. 22, 23 The Eppendorf pO 2 histograph, also referred to as the polarographic electrode, was introduced in the early 1990s and revolutionized in vivo oxygenation measurements. 24 It quickly became the “gold-standard” in oxygen tension ...
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Jan 1, 2020 · This mechanism enables people to adapt to living at high altitudes and bring more oxygen to cells during exercise — but it can also be hijacked by cancer cells for their own survival. The relationship between cancer cells and oxygen is complicated, and, even with the discoveries of Kaelin and others, still being investigated.
