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ATG Entertainment [6] formerly The Ambassador Theatre Group (ATG), is a major international live entertainment organisation headquartered in the United Kingdom, with offices in Woking (head office), London, New York, Sydney, Mannheim and Cologne. ATG's key operations comprise three inter-related activities: venue ownership and management, ticketing and marketing operations, and show productions.
Oct 27, 2021 · Abstract. Idiopathic acquired aplastic anemia can be successfully treated with Anti Thymocyte Globulin (ATG)-based immune suppressive therapy and is therefore considered a T cell-mediated auto immune disease. Based on this finding, several other forms of idiopathic acquired bone marrow failure are treated with ATG as well.
- Jennifer M.-L. Tjon, Saskia M. C. Langemeijer, Constantijn J. M. Halkes
- 2021
Anti-thymocyte globulin (ATG) is an infusion of horse or rabbit-derived antibodies against human T cells and their precursors (thymocytes), which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic anemia due to bone marrow insufficiency.
Mar 18, 2022 · Based on an optimal sampling scheme, peak and trough samples are taken during the first 3 days of once-daily dosing. The fraction of ATG able to bind to T-cells (active ATG) is analyzed using a bio-assay in which Jurkat cells are co-cultured with patient’s plasma and the binding is quantified using flow cytometry.
- 10.3389/fphar.2022.828094
- 2022
- Front Pharmacol. 2022; 13: 828094.
Apr 5, 2007 · The underlying mechanisms of T-cell depletion by ATG include complement-dependent lysis, predominantly in the blood compartment. Indeed, complement-dependent lysis is likely to contribute to the ...
- M Mohty
- mohtym@marseille.fnclcc.fr
- 2007
Oct 25, 2016 · In conclusion, ATG is not a first-line treatment for ABMR because of its poor in vivo effect on B cell biology and the lack of evidence-based trials showing its efficacy in this indication. Nevertheless, ATG might be considered in patients with TCMR-associated acute ABMR, provided that infection prevention and monitoring is provided because of the higher risk of infection-associated death when ...
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On univariate analyses, the use of ATG(2)/PTCy was associated with a lower risk of NRM (hazard ratio, .54; P = .023) compared with the use of ATG-based prophylaxis without PTCy. ATG(2)/PTCy prophylaxis effectively prevents GVHD and is associated with comparable relapse risk, OS, and GRFS as seen with ATG(4.5)/PTCy and ATG-based prophylaxis ...
