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- A review of the literature finds that AEDs, particularly those that block sodium channels and/or have GABA-related mechanisms of action, are effective in reducing the frequency and intensity of impulsive aggressive outbursts both when used as the primary agent of treatment and as an adjunct to ongoing pharmacotherapy.
pubmed.ncbi.nlm.nih.gov/19744405/
People also ask
Does antiepileptic medication treat aggression and impulsivity?
Can psychotropic agents be used to treat impulsive aggression?
Can pharmacotherapy treat impulsive aggression?
Can psychostimulants treat impulsive aggression?
Are tiagabine and gabapentin effective for impulsive aggression?
Four antiepileptic drugs (valproate/divalproex, carbamazepine, oxcarbazepine and phenytoin) helped to reduce aggression in at least one study. However, for three of these drugs (valproate, carbamazepine and phenytoin) we found at least one other study where there was no significant improvement.
Strong evidence for efficacy in impulsive aggression exists from randomized controlled trials for most of the common AEDs (phenytoin, carbamazepine, oxcarbazepine, lamotrigine, valproate/divalproex sodium, topiramate). Additional controlled studies are needed for tiagabine and gabapentin.
- Matthew S. Stanford, Nathaniel E. Anderson, Sarah L. Lake, Robyn M. Baldridge
- 2009
Feb 17, 2010 · Antiepileptic drugs may reduce aggression by acting on the central nervous system to reduce neuronal hyper-excitability associated with aggression. Objectives: To evaluate the efficacy of antiepileptic drugs in reducing aggression and associated impulsivity.
- Nick Huband, Michael Ferriter, Rajan Nathan, Hannah Jones
- 2010
We review here evidence that suggest that antiepileptic drugs (AEDs) (a.k.a. anti- convulsants) may be effective for the treatment of impulsivity and aggression across a range of psychiatric disorders.
Dec 1, 2015 · A rational algorithm for effective pharmacotherapy for impulsive aggression takes into account five factors: sufficiently defined and characterized aggressive behavior; availability of agents studied by trials of sufficient quality; risks, side effects, and contraindications; severity of aggressive outbursts; and co-occurring mental and medical ...
Anti-Epileptic Drugs (AEDs) have become an appealing alternative in the treatment of aggression, mood lability and impulsivity in adult and pediatric populations, although few controlled trials have explored their efficacy in treating pediatric populations.
Do antiepileptic drugs reduce aggression and associated impulsivity? Outcomes: Primary outcome: observer or self-reported aggression (Overt Aggression Scale (OAS), modified forms of the OAS (OAS-M, MOAS), self-reported incidents, Children's Psychiatric Rating Scale (CPRS) aggression subscale).
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Find Provider Dosing And Administration Information for an Available Adult Treatment. Discover a Daily Treatment Option for Adults With Partial-Onset Seizures.
Review Efficacy Data & Safety Information on This Focal Seizure Treatment on The HCP Site. Access Efficacy & Important Safety Information on the Physician Site.
