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Dynamic instability
- Microtubules are cytoskeletal components involved in pivotal eukaryotic functions such as cell division, ciliogenesis, and intracellular trafficking. They assemble from αβ-tubulin heterodimers and disassemble in a process called dynamic instability, which is driven by GTP hydrolysis.
www.ncbi.nlm.nih.gov/pmc/articles/PMC7491153/The Mechanism of Tubulin Assembly into Microtubules: Insights ...
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Sep 9, 2020 · Microtubules are cytoskeletal components involved in pivotal eukaryotic functions such as cell division, ciliogenesis, and intracellular trafficking. They assemble from αβ-tubulin heterodimers and disassemble in a process called dynamic instability, which is driven by GTP hydrolysis.
- Microtubules - The Cell - NCBI Bookshelf
Because of their inherent dynamic instability, most...
- Microtubules and Microtubule-Associated Proteins - PMC
Dynamic instability allows microtubules to explore...
- Microtubules - The Cell - NCBI Bookshelf
Aug 18, 2021 · In cells, microtubules are dynamically assembled and disassembled at their growing (plus) tips.
- Nikita B Gudimchuk, Nikita B Gudimchuk, J Richard McIntosh
- 2021
Apr 19, 2018 · Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular organization, organelle trafficking and chromosome segregation.
- Gary J. Brouhard, Luke M. Rice
- 2018
Because of their inherent dynamic instability, most microtubules are frequently disassembled within the cell. This dynamic behavior can, however, be modified by the interactions of microtubules with other proteins.
- Geoffrey M Cooper
- 2000
Dynamic instability allows microtubules to explore intracellular space and remodel in response to intracellular and extracellular cues. Here, we review how such instability is central to the assembly of many microtubule-based structures and to the robust functioning of the microtubule cytoskeleton. Go to: 1.
- Holly V. Goodson, Erin M. Jonasson
- 10.1101/cshperspect.a022608
- 2018
- 2018/06
Jul 28, 2020 · Supramolecular assembly. Abstract. Microtubules are dynamic tubulin polymers responsible for many cellular processes, including the capture and segregation of chromosomes during mitosis.
Jul 4, 2022 · Assembled from tubulin, a heterodimeric protein with α- and β-tubulin subunits, microtubules are long, hollow cylindrical filaments with inherent polarity. They are intrinsically dynamic polymers that utilize GTP binding by tubulin, and subsequent hydrolysis, to drive spontaneous assembly and disassembly.
