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  1. Aug 12, 2020 · As well as physically missing data, there will be additional concern for participants providing data during Covid-19 when their outcomes are influenced by it. In this situation, a central consideration is the treatment effect to be obtained from the trial (estimand), as this may sometimes require treating some of the collected data as missing.

    • Suzie Cro, Tim P Morris, Brennan C Kahan, Victoria R Cornelius, James R Carpenter
    • 2020
  2. Apr 16, 2019 · When data are MNAR, we need to specify a joint model for the observed and missing outcomes and the missing data pattern. There are two popular models for doing so, selection and pattern mixture models. 29 Pattern-mixture models use the marginal distribution of the missing data pattern and the conditional distribution of the observed and missing ...

    • Dimitris Mavridis, Dimitris Mavridis, Ian R. White
    • 2020
  3. Feb 24, 2021 · When there are only missing data in the outcome (which may be cross sectional or longitudinal), Subsection 5.1 showed that maximising the likelihood of the observed data gives valid inference (provided we choose an appropriate covariance structure).

    • James R Carpenter, Melanie Smuk
    • 2021
  4. When there are only missing data in the outcome (which may be cross sectional or longitudinal), Subsection 5.1 showed that maximising the likelihood of the observed data gives valid inference (provided we choose an appropriate covariance structure).

  5. May 10, 2018 · Missing outcome information: It should be noted that up to this point, this article has focused primarily on missing covariate information. That is because when there are missing outcome data, it has been argued that the complete case analysis is more appropriate as imputed outcome data can lead to misleading results [14, 15]. Single imputation ...

    • Grigorios Papageorgiou, Stuart W Grant, Johanna J M Takkenberg, Mostafa M Mokhles
    • 2018
  6. Feb 1, 2024 · Missing data are data that we planned to collect to answer a research question, such as participant characteristics at the start of the study or their health outcomes after receiving some treatments, but for some reason we were not able to. In practice there are various ways in which missing data can arise.

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  8. Aug 26, 2020 · One challenge when handling missing data is the lack of clarity in trial reports on whether participants have missing outcome data.12 We recently published guidance for authors of systematic reviews on how to identify and classify participants with missing outcome data in the trial reports.13 The Cochrane Handbook acknowledges that attempts to deal with missing data in systematic reviews are ...

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