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1. my.clevelandclinic.org › 23951-tangier-diseaseTangier Disease: Symptoms & Treatment - Cleveland Clinic

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   Symptoms can include: Pain in your stomach or feeling sick to your stomach. Plaque collecting in your arteries (atherosclerosis). Dry skin. Ectropion (your eyelid flips inside out). Anemia. Muscle weakness in your arms, legs hands or feet. Long-term lymph node swelling that doesn’t come from an infection.

2. www.medicalnewstoday.com › articles › tangier-diseaseTangier disease: Causes, symptoms, and treatment

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   Mar 14, 2024 · Tangier disease is an inherited metabolic condition. It occurs due to a problem with an enzyme that processes cholesterol. This can cause an accumulation of toxic cholesterol in certain body tissues.

3. medlineplus.gov › genetics › conditionTangier disease - MedlinePlus

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   Tangier disease is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell must have a variant to cause the disorder. The parents of an individual with an autosomal recessive condition each carry one copy of the altered gene, but they typically do not show signs and symptoms of the condition; however, they may have a related condition called familial HDL ...

4. rarediseases.org › rare-diseases › tangTangier Disease - Symptoms, Causes, Treatment | NORD

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   Jul 10, 2017 · Tangier disease is a rare inherited disorder characterized by significantly reduced levels of high-density lipoproteins (HDL) in the blood. HDL-cholesterol (HDL-C) is often referred to as the “good cholesterol” as it can facilitate the removal of cholesterol out of the walls of arteries, particularly the coronary (heart) arteries.

5. www.ncbi.nlm.nih.gov › books › NBK562250Tangier Disease - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov › books › NBK562250

   May 8, 2023 · Tangier disease is an inherited condition, first described in two siblings from the Tangier island of Virginia in the Chesapeake Bay in 1961 and named after the island. There is a significant decrease in HDL, which is also known as the good cholesterol, and accumulation of cholesterol esters in many organs within the body, particularly the reticuloendothelial systems. These organs will appear ...

   • Author: Alfarooq Alshaikhli, Sarosh Vaqar
   • Published: 2023/05/08

   • Affiliations: University of Texas/ Rio Grande Valley at DHR

6. en.wikipedia.org › wiki › Tangier_diseaseTangier disease - Wikipedia

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   Tangier disease or hypoalphalipoproteinemia is an extremely rare inherited disorder characterized by a severe reduction in the amount of high density lipoprotein (HDL), often referred to as "good cholesterol ", in the bloodstream. [2] Worldwide, approximately 100 cases have even been identified. [3][4]

7. People also ask

   Can Tangier disease be inherited?

   • Tangier disease is a very rare disease that you can inherit from your parents. People with Tangier disease have very little HDL, or the “good cholesterol” that helps you get rid of LDL or “bad cholesterol.” This allows LDL to build up in various parts of your body, such as your tonsils. It can also raise your risk of heart disease.

   Tangier Disease: Symptoms & Treatment - Cleveland Clinic

   my.clevelandclinic.org/health/diseases/23951-tangier-disease

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   Is Tangier disease autosomal recessive?

   • Tangier disease is an autosomal recessive genetic condition. This means a person must inherit a gene variation for Tangier disease from both parents to develop the condition. If a person inherits one copy of the gene variation, they are known as a carrier.

   Tangier disease: Causes, symptoms, and treatment - Medical News Today

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   Can you get Tangier disease from your parents?

   • Tangier disease is a rare condition you can get from your parents. People with Tangier disease have very low levels of HDL (high-density lipoprotein). This type of cholesterol is known as “good cholesterol” because it helps get rid of the bad kind of cholesterol (LDL or low-density lipoprotein) that clogs your arteries.

   Tangier Disease: Symptoms & Treatment - Cleveland Clinic

   my.clevelandclinic.org/health/diseases/23951-tangier-disease

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   How rare is Tangier disease?

   • Tangier disease is a rare disorder with only approximately 100 cases diagnosed worldwide. Tangier disease is thought to be present at birth, but the age of diagnosis can be highly variable (from infancy through 7th decade) due to the nature of symptoms. Symptoms of the following disorders can be similar to those of multiple sclerosis.

   Tangier Disease - Symptoms, Causes, Treatment | NORD

   rarediseases.org/rare-diseases/tangier-disease/

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   What causes Tangier disease?

   • Tangier disease is a genetic metabolic disease. It occurs due to problems with the ATP-binding cassette transporter A1 (ABCA1) protein. This enzyme helps transport cholesterol out of cells, where it then turns into good cholesterol, also known as high-density lipoprotein (HDL).

   Tangier disease: Causes, symptoms, and treatment - Medical News Today

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8. rarediseases.info.nih.gov › diseases › 7731Tangier disease | About the Disease | GARD - Genetic and Rare ...

   rarediseases.info.nih.gov › diseases › 7731

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   Summary. Tangier disease is an inherited disorder characterized by significantly reduced levels of high-density lipoprotein (HDL) - the 'good cholesterol' - in the blood. Because people with Tangier disease have very low levels of HDL, they have a moderately increased risk of cardiovascular disease. Tangier disease is caused by genetic changes ...